Abelacimab / 6r8x

A4DAB003_6r8x_C_B | Source PDB: 6r8x | Chains: C, B | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6113
Max Score
2.7466
Min Score
-3.125
Total Score
-262.86
Score CDR
-0.0712
Score non-CDR
-0.6872

Calculation Parameters

Chain Sequence(s) QVQLLESGGGLVQPGGSLRLSCAASGFTFSTAAMSWVRQAPGKGLEWVSGISGSGSSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARELSYLYSGYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKVLTQPPSASGTPGQRVTISCSGSSSNIGSNDVSWYQQLPGTAPKLLIYKNYNRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCSAWDQRQFDVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT input.pdb
Selected Chain(s) C (Heavy), B (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.125
Maximum Score 2.7466
Average Score -0.6113
Total Score -262.8646

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q C -1.4335 Soluble
2 V C -0.6633 Soluble
3 Q C -1.0730 Soluble
4 L C 0.0000 Buried
5 L C 0.5189 Aggregation-prone
6 E C 0.0000 Buried
7 S C -0.4295 Soluble
8 G C -0.8400 Soluble
9 G C -0.2844 Soluble
11 G C -0.3267 Soluble
12 L C 0.0134 Aggregation-prone
13 V C -0.6494 Soluble
14 Q C -1.6269 Soluble
15 P C -1.6819 Soluble
16 G C -1.4704 Soluble
17 G C -1.1222 Soluble
18 S C -1.2339 Soluble
19 L C -1.0898 Soluble
20 R C -2.2211 Soluble
21 L C 0.0000 Buried
22 S C -0.5414 Soluble
23 C C 0.0000 Buried
24 A C -0.4114 Soluble
25 A C 0.0000 Buried
26 S C -0.7831 Soluble
27 G C -0.9606 Soluble
28 F C -0.3779 Soluble
29 T C -0.2152 Soluble
30 F C 0.0000 Buried
35 S C -0.8185 Soluble
36 T C -0.2203 Soluble
37 A C 0.0000 Buried
38 A C -0.2212 Soluble
39 M C 0.0000 Buried
40 S C 0.0000 Buried
41 W C 0.0000 Buried
42 V C 0.0000 Buried
43 R C 0.0000 Buried
44 Q C -0.7643 Soluble
45 A C -1.1345 Soluble
46 P C -0.8932 Soluble
47 G C -1.4407 Soluble
48 K C -2.2873 Soluble
49 G C -1.4624 Soluble
50 L C 0.0000 Buried
51 E C -1.2365 Soluble
52 W C 0.0000 Buried
53 V C 0.0000 Buried
54 S C 0.0000 Buried
55 G C 0.0000 Buried
56 I C 0.0000 Buried
57 S C -0.2952 Soluble
58 G C -0.5334 Soluble
59 S C -0.6606 Soluble
62 G C -0.7166 Soluble
63 S C -0.5074 Soluble
64 S C -0.2773 Soluble
65 T C 0.1712 Aggregation-prone
66 Y C 0.3685 Aggregation-prone
67 Y C -0.4650 Soluble
68 A C -1.0293 Soluble
69 D C -2.3170 Soluble
70 S C -1.6585 Soluble
71 V C 0.0000 Buried
72 K C -2.3479 Soluble
74 G C -1.5802 Soluble
75 R C 0.0000 Buried
76 F C 0.0000 Buried
77 T C -0.7771 Soluble
78 I C 0.0000 Buried
79 S C -0.5635 Soluble
80 R C -1.1662 Soluble
81 D C -1.8800 Soluble
82 N C -1.8054 Soluble
83 S C -1.6665 Soluble
84 K C -2.5093 Soluble
85 N C -1.9001 Soluble
86 T C 0.0000 Buried
87 L C 0.0000 Buried
88 Y C -0.7310 Soluble
89 L C 0.0000 Buried
90 Q C -1.4484 Soluble
91 M C 0.0000 Buried
92 N C -1.2663 Soluble
93 S C -1.1763 Soluble
94 L C 0.0000 Buried
95 R C -2.3642 Soluble
96 A C -1.7578 Soluble
97 E C -2.2598 Soluble
98 D C 0.0000 Buried
99 T C -0.6066 Soluble
100 A C 0.0000 Buried
101 V C 0.4564 Aggregation-prone
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 A C 0.0000 Buried
106 R C -0.1453 Soluble
107 E C 0.0000 Buried
108 L C 0.8538 Aggregation-prone
109 S C 1.2861 Aggregation-prone
110 Y C 2.5339 Aggregation-prone
111 L C 2.7466 Aggregation-prone
111A Y C 2.3848 Aggregation-prone
112A S C 0.0000 Buried
112 G C 0.9541 Aggregation-prone
113 Y C 0.7148 Aggregation-prone
114 Y C 0.2514 Aggregation-prone
115 F C 0.0000 Buried
116 D C -0.2349 Soluble
117 Y C 0.0150 Aggregation-prone
118 W C -0.3242 Soluble
119 G C 0.0000 Buried
120 Q C -1.0059 Soluble
121 G C -0.2107 Soluble
122 T C 0.3066 Aggregation-prone
123 L C 0.8523 Aggregation-prone
124 V C 0.0000 Buried
125 T C -0.3177 Soluble
126 V C 0.0000 Buried
127 S C -0.9480 Soluble
128 S C -0.7054 Soluble
129 A C -0.4429 Soluble
130 S C -0.5645 Soluble
131 T C -0.7092 Soluble
132 K C -1.0210 Soluble
133 G C -1.2663 Soluble
134 P C 0.0000 Buried
135 S C -0.1983 Soluble
136 V C 0.0000 Buried
137 F C -0.6015 Soluble
138 P C -0.9841 Soluble
139 L C 0.0000 Buried
140 A C -1.2024 Soluble
141 P C 0.0000 Buried
142 S C -0.7500 Soluble
143 S C -0.7385 Soluble
144 G C -0.8185 Soluble
145 G C -0.8657 Soluble
146 T C -0.5924 Soluble
147 A C 0.0000 Buried
148 A C -0.1193 Soluble
149 L C 0.0000 Buried
150 G C 0.0000 Buried
151 C C 0.0000 Buried
152 L C 0.0000 Buried
153 V C 0.0000 Buried
154 K C 0.0000 Buried
155 D C -0.2366 Soluble
156 Y C 0.0000 Buried
157 F C -0.3594 Soluble
158 P C 0.0000 Buried
159 E C -1.1260 Soluble
160 P C -1.0497 Soluble
161 V C -0.6170 Soluble
162 T C -0.5683 Soluble
163 V C -0.0990 Soluble
164 S C -0.3402 Soluble
165 W C 0.0000 Buried
166 N C -0.7541 Soluble
167 S C -0.6591 Soluble
168 G C -0.5575 Soluble
169 A C -0.2157 Soluble
170 L C 0.0365 Aggregation-prone
171 T C -0.2084 Soluble
172 S C -0.2880 Soluble
173 G C -0.3725 Soluble
174 V C 0.1250 Aggregation-prone
175 H C -0.1651 Soluble
176 T C -0.0329 Soluble
177 F C 0.0000 Buried
178 P C -0.0753 Soluble
179 A C 0.1935 Aggregation-prone
180 V C 0.0000 Buried
181 L C 1.2404 Aggregation-prone
182 Q C 0.3461 Aggregation-prone
183 S C -0.1148 Soluble
184 S C -0.1801 Soluble
185 G C 0.0627 Aggregation-prone
186 L C 0.1465 Aggregation-prone
187 Y C 0.3487 Aggregation-prone
188 S C 0.0000 Buried
189 L C 0.0000 Buried
190 S C 0.0000 Buried
191 S C 0.0000 Buried
192 V C 0.1607 Aggregation-prone
193 V C 0.0000 Buried
194 T C -0.1990 Soluble
195 V C 0.0000 Buried
196 P C -0.5842 Soluble
197 S C -0.5769 Soluble
198 S C -0.5847 Soluble
199 S C -0.5269 Soluble
200 L C -0.7001 Soluble
201 G C -1.0629 Soluble
202 T C -0.6669 Soluble
203 Q C -1.2027 Soluble
204 T C -1.1032 Soluble
205 Y C 0.0000 Buried
206 I C -1.2114 Soluble
207 C C 0.0000 Buried
208 N C -1.5091 Soluble
209 V C 0.0000 Buried
210 N C -1.7398 Soluble
211 H C 0.0000 Buried
212 K C -2.7862 Soluble
213 P C -1.6924 Soluble
214 S C -1.7158 Soluble
215 N C -2.5579 Soluble
216 T C -1.9970 Soluble
217 K C -2.6644 Soluble
218 V C -1.6810 Soluble
219 D C -2.6109 Soluble
220 K C -2.2863 Soluble
221 R C -2.6835 Soluble
222 V C 0.0000 Buried
223 E C -2.8098 Soluble
224 P C -1.9134 Soluble
225 K C -2.2706 Soluble
3 V B 1.5206 Aggregation-prone
4 L B 0.0000 Buried
5 T B 0.0388 Aggregation-prone
6 Q B 0.0000 Buried
7 P B -0.6873 Soluble
8 P B -0.9784 Soluble
9 S B -1.0574 Soluble
11 A B -0.7584 Soluble
12 S B -0.6833 Soluble
13 G B 0.0000 Buried
14 T B -0.9178 Soluble
15 P B -1.5527 Soluble
16 G B -1.7780 Soluble
17 Q B -2.3999 Soluble
18 R B -2.6126 Soluble
19 V B 0.0000 Buried
20 T B -0.5929 Soluble
21 I B 0.0000 Buried
22 S B -0.3820 Soluble
23 C B 0.0000 Buried
24 S B -0.2404 Soluble
25 G B -0.0686 Soluble
26 S B -0.2543 Soluble
27 S B -0.9718 Soluble
28 S B 0.0000 Buried
29 N B 0.0000 Buried
30 I B 0.0000 Buried
35 G B -0.9591 Soluble
36 S B -0.8075 Soluble
37 N B -0.6269 Soluble
38 D B -0.2511 Soluble
39 V B 0.0000 Buried
40 S B 0.0000 Buried
41 W B 0.0000 Buried
42 Y B 0.0000 Buried
43 Q B 0.0000 Buried
44 Q B -0.7369 Soluble
45 L B -0.7155 Soluble
46 P B -0.4991 Soluble
47 G B -0.7047 Soluble
48 T B -0.7732 Soluble
49 A B -0.7924 Soluble
50 P B 0.0000 Buried
51 K B -1.4056 Soluble
52 L B 0.0000 Buried
53 L B 0.0000 Buried
54 I B 0.0000 Buried
55 Y B -0.1629 Soluble
56 K B -0.4596 Soluble
57 N B -0.3465 Soluble
65 Y B 0.4333 Aggregation-prone
66 N B -0.4786 Soluble
67 R B -1.3981 Soluble
68 P B -0.7123 Soluble
69 S B -0.7616 Soluble
70 G B -1.0071 Soluble
71 V B 0.0000 Buried
72 P B -1.4591 Soluble
74 D B -2.2823 Soluble
75 R B -1.5374 Soluble
76 F B 0.0000 Buried
77 S B -0.6207 Soluble
78 G B 0.0000 Buried
79 S B -0.4274 Soluble
80 K B -0.9421 Soluble
83 S B -0.8977 Soluble
84 G B -0.9927 Soluble
85 T B -0.8495 Soluble
86 S B -0.8106 Soluble
87 A B 0.0000 Buried
88 S B -0.3669 Soluble
89 L B 0.0000 Buried
90 A B -0.6489 Soluble
91 I B 0.0000 Buried
92 S B -1.8777 Soluble
93 G B -1.7870 Soluble
94 L B 0.0000 Buried
95 Q B -1.8030 Soluble
96 S B -1.6457 Soluble
97 E B -2.2372 Soluble
98 D B 0.0000 Buried
99 E B -1.3779 Soluble
100 A B 0.0000 Buried
101 D B 0.0000 Buried
102 Y B 0.0000 Buried
103 Y B 0.0000 Buried
104 C B 0.0000 Buried
105 S B 0.0000 Buried
106 A B 0.0000 Buried
107 W B -0.2823 Soluble
108 D B 0.0000 Buried
109 Q B -1.8098 Soluble
110 R B -2.4233 Soluble
113 Q B -1.3423 Soluble
114 F B 0.2175 Aggregation-prone
115 D B -0.3181 Soluble
116 V B 0.0000 Buried
117 V B 0.4464 Aggregation-prone
118 F B 0.0000 Buried
119 G B 0.0000 Buried
120 G B -0.9564 Soluble
121 G B 0.0000 Buried
122 T B 0.0000 Buried
123 K B -1.9766 Soluble
124 L B 0.0000 Buried
125 T B -0.6565 Soluble
126 V B 0.0000 Buried
127 L B 0.0929 Aggregation-prone
128 G B -0.5864 Soluble
129 Q B -0.8992 Soluble
130 P B -1.2233 Soluble
131 K B -2.2325 Soluble
132 A B -1.2632 Soluble
133 A B -0.6729 Soluble
134 P B 0.0000 Buried
135 S B -0.5785 Soluble
136 V B 0.0000 Buried
137 T B -0.4149 Soluble
138 L B -0.4018 Soluble
139 F B 0.0000 Buried
140 P B -0.0622 Soluble
141 P B 0.0000 Buried
142 S B -1.1775 Soluble
143 S B -1.7656 Soluble
144 E B -2.5473 Soluble
145 E B 0.0000 Buried
146 L B -2.0915 Soluble
147 Q B -2.4316 Soluble
148 A B -2.0079 Soluble
149 N B -2.8401 Soluble
150 K B -2.9290 Soluble
151 A B 0.0000 Buried
152 T B 0.0000 Buried
153 L B 0.0000 Buried
154 V B 0.0000 Buried
155 C B 0.0000 Buried
156 L B 0.0000 Buried
157 I B 0.0000 Buried
158 S B -0.5712 Soluble
159 D B -1.2882 Soluble
160 F B 0.0000 Buried
161 Y B -1.1439 Soluble
162 P B -0.8832 Soluble
163 G B -0.5437 Soluble
164 A B -0.1705 Soluble
165 V B -0.0315 Soluble
166 T B -0.0908 Soluble
167 V B 0.3629 Aggregation-prone
168 A B -0.4373 Soluble
169 W B 0.0000 Buried
170 K B -0.9631 Soluble
171 A B 0.0000 Buried
172 D B -1.2788 Soluble
173 S B -0.8494 Soluble
174 S B -0.7625 Soluble
175 P B -0.8976 Soluble
176 V B -0.8952 Soluble
177 K B -1.7118 Soluble
178 A B -0.8673 Soluble
179 G B -0.7436 Soluble
180 V B -0.4132 Soluble
181 E B -0.2735 Soluble
182 T B 0.0928 Aggregation-prone
183 T B 0.0690 Aggregation-prone
184 T B -0.1174 Soluble
185 P B -0.3513 Soluble
186 S B -0.6300 Soluble
187 K B -1.4367 Soluble
188 Q B -1.3833 Soluble
189 S B -1.4430 Soluble
190 N B -1.9092 Soluble
191 N B -1.7607 Soluble
192 K B -1.7171 Soluble
193 Y B -0.9198 Soluble
194 A B 0.0000 Buried
195 A B 0.0000 Buried
196 S B 0.0000 Buried
197 S B 0.0000 Buried
198 Y B 0.0000 Buried
199 L B 0.0000 Buried
200 S B -0.6567 Soluble
201 L B 0.0000 Buried
202 T B -1.8746 Soluble
203 P B -2.4728 Soluble
204 E B -3.1250 Soluble
205 Q B -2.2519 Soluble
206 W B 0.0000 Buried
207 K B -3.0955 Soluble
208 S B -2.3622 Soluble
209 H B -2.3366 Soluble
210 R B -2.5013 Soluble
211 S B -1.4868 Soluble
212 Y B 0.0000 Buried
213 S B -0.9973 Soluble
214 C B 0.0000 Buried
215 Q B -1.0170 Soluble
216 V B 0.0000 Buried
217 T B -0.6476 Soluble
218 H B 0.0000 Buried
219 E B -2.2423 Soluble
220 G B -1.4142 Soluble
221 S B -0.8528 Soluble
222 T B -0.7049 Soluble
223 V B -0.7082 Soluble
224 E B -2.0926 Soluble
225 K B -1.8445 Soluble
226 T B -1.0005 Soluble
227 V B -0.3545 Soluble
228 A B -0.7879 Soluble
229 P B -0.9367 Soluble
230 T B -0.6837 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6048 3.0856 CSV PDB
4.5 -0.6358 3.0765 CSV PDB
5.0 -0.6714 3.0667 CSV PDB
5.5 -0.7035 3.0566 CSV PDB
6.0 -0.7231 3.0464 CSV PDB
6.5 -0.7226 3.0361 CSV PDB
7.0 -0.7023 3.026 CSV PDB
7.5 -0.6694 3.0159 CSV PDB
8.0 -0.63 3.0061 CSV PDB
8.5 -0.5863 2.9968 CSV PDB
9.0 -0.5388 2.986 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH