Tamrintamab / 6vgr

A4DAB254_6vgr_H_L | Source PDB: 6vgr | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6605
Max Score
2.0361
Min Score
-3.7552
Total Score
-284.7
Score CDR
-0.1157
Score non-CDR
-0.7337

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYWIEWVRQAPGQGLEWMGEILPGSGNTYYNERFKDRVTITADESTSTAYMELSSLRSEDTAVYYCARRAAAYYSNPEWFAYWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPEIVLTQSPATLSLSPGERATLSCTASSSVNSFYLHWYQQKPGLAPRLLIYSTSNLASGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCHQYHRSPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7552
Maximum Score 2.0361
Average Score -0.6605
Total Score -284.6968

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.5821 Soluble
2 V H -1.0122 Soluble
3 Q H -1.5184 Soluble
4 L H 0.0000 Buried
5 V H -0.3910 Soluble
6 Q H 0.0000 Buried
7 S H -0.7106 Soluble
8 G H -0.6225 Soluble
9 A H -0.1572 Soluble
11 E H -0.6071 Soluble
12 V H -0.1378 Soluble
13 K H -1.3792 Soluble
14 K H -2.1812 Soluble
15 P H -2.2027 Soluble
16 G H -1.6442 Soluble
17 S H -1.2706 Soluble
18 S H -1.4358 Soluble
19 V H 0.0000 Buried
20 K H -2.1218 Soluble
21 V H 0.0000 Buried
22 S H -0.7015 Soluble
23 C H 0.0000 Buried
24 K H -1.1513 Soluble
25 A H -0.8353 Soluble
26 S H -1.1105 Soluble
27 G H -1.3084 Soluble
28 G H -0.9809 Soluble
29 T H -0.4913 Soluble
30 F H -0.7175 Soluble
35 S H -0.6184 Soluble
36 S H -0.1740 Soluble
37 Y H -0.0207 Soluble
38 W H 0.0000 Buried
39 I H 0.0000 Buried
40 E H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H -0.3740 Soluble
44 Q H -0.5983 Soluble
45 A H -0.9383 Soluble
46 P H -0.8137 Soluble
47 G H -1.2470 Soluble
48 Q H -1.8815 Soluble
49 G H -1.3696 Soluble
50 L H 0.0000 Buried
51 E H -0.7682 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 E H 0.0000 Buried
56 I H 0.0000 Buried
57 L H -0.1327 Soluble
58 P H 0.0000 Buried
59 G H -1.0823 Soluble
62 S H -0.7537 Soluble
63 G H -0.9439 Soluble
64 N H -0.5332 Soluble
65 T H 0.2669 Aggregation-prone
66 Y H 0.6532 Aggregation-prone
67 Y H -0.7395 Soluble
68 N H -2.1972 Soluble
69 E H -3.5601 Soluble
70 R H -3.5384 Soluble
71 F H 0.0000 Buried
72 K H -3.7552 Soluble
74 D H -3.3990 Soluble
75 R H -2.1035 Soluble
76 V H 0.0000 Buried
77 T H -0.9787 Soluble
78 I H 0.0000 Buried
79 T H -0.3301 Soluble
80 A H -0.9922 Soluble
81 D H -1.7327 Soluble
82 E H -2.2578 Soluble
83 S H -1.2651 Soluble
84 T H -1.0913 Soluble
85 S H -1.3116 Soluble
86 T H -1.0058 Soluble
87 A H 0.0000 Buried
88 Y H -0.6734 Soluble
89 M H 0.0000 Buried
90 E H -1.6023 Soluble
91 L H 0.0000 Buried
92 S H -1.4058 Soluble
93 S H -1.4014 Soluble
94 L H 0.0000 Buried
95 R H -3.1070 Soluble
96 S H -2.3615 Soluble
97 E H -2.5583 Soluble
98 D H 0.0000 Buried
99 T H -0.8896 Soluble
100 A H 0.0000 Buried
101 V H 0.3422 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 R H -0.1771 Soluble
108 A H 0.2056 Aggregation-prone
109 A H 0.4532 Aggregation-prone
110 A H 0.9149 Aggregation-prone
111 Y H 1.9277 Aggregation-prone
111A Y H 2.0361 Aggregation-prone
112B S H 0.7202 Aggregation-prone
112A N H 0.6396 Aggregation-prone
112 P H -0.1465 Soluble
113 E H -0.3204 Soluble
114 W H 0.0000 Buried
115 F H 0.0000 Buried
116 A H -0.2886 Soluble
117 Y H -0.0102 Soluble
118 W H -0.0867 Soluble
119 G H 0.0000 Buried
120 Q H -0.8385 Soluble
121 G H -0.2100 Soluble
122 T H 0.0000 Buried
123 L H 0.3181 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -1.3287 Soluble
128 S H -1.1749 Soluble
129 A H -0.6778 Soluble
130 S H -0.7738 Soluble
131 T H -0.8234 Soluble
132 K H -1.7110 Soluble
133 G H -1.5141 Soluble
134 P H 0.0000 Buried
135 S H -0.3825 Soluble
136 V H 0.0000 Buried
137 F H -0.4744 Soluble
138 P H -0.8687 Soluble
139 L H 0.0000 Buried
140 A H -0.7305 Soluble
141 P H 0.0000 Buried
142 S H -0.1783 Soluble
143 G H -0.6504 Soluble
144 T H -0.4965 Soluble
145 A H -0.2526 Soluble
146 A H 0.0000 Buried
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.0000 Buried
151 V H 0.0000 Buried
152 K H 0.0000 Buried
153 D H -0.6825 Soluble
154 Y H 0.0000 Buried
155 F H 0.0000 Buried
156 P H 0.0000 Buried
157 E H -0.4267 Soluble
158 P H -0.7274 Soluble
159 V H -0.6219 Soluble
160 T H -0.5226 Soluble
161 V H -0.2515 Soluble
162 S H -0.3075 Soluble
163 W H 0.0000 Buried
164 N H -0.5959 Soluble
165 S H -0.5959 Soluble
166 G H -0.5315 Soluble
167 A H -0.2180 Soluble
168 L H 0.0370 Aggregation-prone
169 T H -0.1402 Soluble
170 S H -0.1540 Soluble
171 G H -0.1789 Soluble
172 V H 0.1841 Aggregation-prone
173 H H -0.3018 Soluble
174 T H 0.0222 Aggregation-prone
175 F H 0.0000 Buried
176 P H -0.4683 Soluble
177 A H 0.1947 Aggregation-prone
178 V H 0.4401 Aggregation-prone
179 L H 0.8625 Aggregation-prone
180 Q H 0.1157 Aggregation-prone
181 S H -0.1686 Soluble
182 S H -0.2542 Soluble
183 G H -0.0338 Soluble
184 L H -0.0858 Soluble
185 Y H 0.2167 Aggregation-prone
186 S H 0.0000 Buried
187 L H 0.1142 Aggregation-prone
188 S H 0.0000 Buried
189 S H 0.0000 Buried
190 V H 0.0000 Buried
191 V H 0.0000 Buried
192 T H -0.1272 Soluble
193 V H 0.0000 Buried
194 P H -0.5495 Soluble
195 S H -0.5550 Soluble
196 S H -0.5617 Soluble
197 S H -0.5042 Soluble
198 L H -0.7078 Soluble
199 G H -1.0313 Soluble
200 T H -0.6062 Soluble
201 Q H -1.0941 Soluble
202 T H -0.9399 Soluble
203 Y H 0.0000 Buried
204 I H -0.9032 Soluble
205 C H 0.0000 Buried
206 N H -1.2012 Soluble
207 V H 0.0000 Buried
208 N H -1.7140 Soluble
209 H H 0.0000 Buried
210 K H -2.7147 Soluble
211 P H -1.7483 Soluble
212 S H -1.9466 Soluble
213 N H -2.6076 Soluble
214 T H -2.0780 Soluble
215 K H -2.4815 Soluble
216 V H -1.2817 Soluble
217 D H -1.8846 Soluble
218 K H -1.7358 Soluble
219 K H -1.9678 Soluble
220 V H 0.0000 Buried
221 E H -2.3669 Soluble
222 P H -1.3167 Soluble
1 E L -1.8415 Soluble
2 I L 0.0000 Buried
3 V L 0.9146 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.2462 Soluble
6 Q L 0.0000 Buried
7 S L -0.5124 Soluble
8 P L -0.3148 Soluble
9 A L -0.4430 Soluble
10 T L -0.2698 Soluble
11 L L -0.1146 Soluble
12 S L -0.4305 Soluble
13 L L -0.9030 Soluble
14 S L -1.5420 Soluble
15 P L -2.0330 Soluble
16 G L -2.4016 Soluble
17 E L -2.8261 Soluble
18 R L -3.1631 Soluble
19 A L 0.0000 Buried
20 T L -0.5494 Soluble
21 L L 0.0000 Buried
22 S L -0.6036 Soluble
23 C L 0.0000 Buried
24 T L -0.6397 Soluble
25 A L 0.0000 Buried
26 S L -0.2598 Soluble
27 S L -0.7576 Soluble
28 S L -0.8898 Soluble
29 V L 0.0000 Buried
30 N L -0.2464 Soluble
36 S L 0.3092 Aggregation-prone
37 F L 1.8537 Aggregation-prone
38 Y L 0.8559 Aggregation-prone
39 L L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -0.5600 Soluble
45 K L -0.7596 Soluble
46 P L -0.5643 Soluble
47 G L -0.1342 Soluble
48 L L 0.5952 Aggregation-prone
49 A L -0.0870 Soluble
50 P L 0.0000 Buried
51 R L -1.4659 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.2310 Aggregation-prone
56 S L 0.6680 Aggregation-prone
57 T L 0.0000 Buried
65 S L -0.3681 Soluble
66 N L -0.7140 Soluble
67 L L -0.3707 Soluble
68 A L -0.4030 Soluble
69 S L -0.3990 Soluble
70 G L -0.6967 Soluble
71 I L 0.0000 Buried
72 P L -1.0983 Soluble
74 D L -2.2187 Soluble
75 R L -1.9498 Soluble
76 F L 0.0000 Buried
77 S L -0.7824 Soluble
78 G L -0.4468 Soluble
79 S L -0.8545 Soluble
80 G L -1.0793 Soluble
83 S L -0.9215 Soluble
84 G L -1.0990 Soluble
85 T L -1.3414 Soluble
86 D L -2.1254 Soluble
87 F L 0.0000 Buried
88 T L -0.6807 Soluble
89 L L 0.0000 Buried
90 T L -0.8017 Soluble
91 I L 0.0000 Buried
92 S L -2.4511 Soluble
93 R L -3.4650 Soluble
94 L L 0.0000 Buried
95 E L -2.4873 Soluble
96 P L -1.7492 Soluble
97 E L -2.2428 Soluble
98 D L 0.0000 Buried
99 F L -0.6950 Soluble
100 A L 0.0000 Buried
101 V L -0.4018 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 H L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L -0.3816 Soluble
108 H L -0.9307 Soluble
109 R L -2.4164 Soluble
114 S L -1.5651 Soluble
115 P L 0.0000 Buried
116 Y L 0.0000 Buried
117 T L -0.4975 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.3905 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -0.9050 Soluble
124 L L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.6083 Soluble
127 K L -1.2014 Soluble
128 R L -0.9647 Soluble
129 T L 0.0141 Aggregation-prone
130 V L 0.5841 Aggregation-prone
131 A L 0.0580 Aggregation-prone
132 A L -0.0601 Soluble
133 P L 0.0000 Buried
134 S L -0.1579 Soluble
135 V L 0.0000 Buried
136 F L 0.0867 Aggregation-prone
137 I L 0.1023 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.4998 Soluble
140 P L 0.0000 Buried
141 S L -1.3092 Soluble
142 D L -2.5342 Soluble
143 E L -2.1882 Soluble
144 Q L 0.0000 Buried
145 L L -1.7777 Soluble
146 K L -2.5200 Soluble
147 S L -1.5528 Soluble
148 G L -1.1065 Soluble
149 T L -0.9031 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.9869 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.7110 Soluble
162 R L -2.8216 Soluble
163 E L -3.1768 Soluble
164 A L -2.2866 Soluble
165 K L -2.2347 Soluble
166 V L -1.1144 Soluble
167 Q L -0.7396 Soluble
168 W L 0.0000 Buried
169 K L -0.7333 Soluble
170 V L 0.0000 Buried
171 D L -1.7110 Soluble
172 N L -1.4379 Soluble
173 A L -0.5076 Soluble
174 L L 0.1451 Aggregation-prone
175 Q L -0.3948 Soluble
176 S L -0.5849 Soluble
177 G L -0.8599 Soluble
178 N L -0.7559 Soluble
179 S L -1.0679 Soluble
180 Q L -1.3612 Soluble
181 E L -1.9024 Soluble
182 S L -0.8120 Soluble
183 V L -0.9025 Soluble
184 T L -1.2083 Soluble
185 E L -2.2779 Soluble
186 Q L -1.9024 Soluble
187 D L -1.9120 Soluble
188 S L -1.8973 Soluble
189 K L -2.2405 Soluble
190 D L -1.7232 Soluble
191 S L -1.6877 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.6269 Soluble
199 L L 0.0000 Buried
200 T L -0.4100 Soluble
201 L L -0.5893 Soluble
202 S L -0.9425 Soluble
203 K L -1.7233 Soluble
204 A L -1.5957 Soluble
205 D L -2.4476 Soluble
206 Y L 0.0000 Buried
207 E L -2.5704 Soluble
208 K L -3.1169 Soluble
209 H L -2.7323 Soluble
210 K L -2.8949 Soluble
211 V L -1.3578 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.7921 Soluble
216 V L 0.0000 Buried
217 T L -1.1876 Soluble
218 H L 0.0000 Buried
219 Q L -1.6864 Soluble
220 G L -0.3472 Soluble
221 L L -0.1630 Soluble
222 S L -0.4216 Soluble
223 S L -0.4124 Soluble
224 P L -0.5190 Soluble
225 V L -0.0125 Soluble
226 T L -0.4963 Soluble
227 K L -0.7827 Soluble
228 S L -0.5625 Soluble
229 F L -0.9456 Soluble
230 N L -1.8910 Soluble
231 R L -2.4023 Soluble
232 G L -2.0238 Soluble
233 E L -2.5148 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6556 3.9781 CSV PDB
4.5 -0.6989 3.9858 CSV PDB
5.0 -0.7513 3.9957 CSV PDB
5.5 -0.8025 4.0039 CSV PDB
6.0 -0.8411 4.0083 CSV PDB
6.5 -0.8572 4.01 CSV PDB
7.0 -0.8491 4.0106 CSV PDB
7.5 -0.8241 4.0107 CSV PDB
8.0 -0.7897 4.0106 CSV PDB
8.5 -0.749 4.0101 CSV PDB
9.0 -0.7027 4.0083 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH