Mevonlerbart / 5vyf

A4DAB170_5vyf_H_L | Source PDB: 5vyf | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7226
Max Score
1.5437
Min Score
-3.3991
Total Score
-302.75
Score CDR
-0.4464
Score non-CDR
-0.7533

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGRGYNADYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLEYFDYWGQGTLVTVSSASTKGPSVFPLSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESDIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKLLIYKASSLESGVPSRFSGSGSGTDFTLTISSLRPEDFATYYCQQYNSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3991
Maximum Score 1.5437
Average Score -0.7226
Total Score -302.7525

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -2.1315 Soluble
2 V H -1.2284 Soluble
3 Q H -1.1062 Soluble
4 L H 0.0000 Buried
5 V H 1.2120 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.1045 Soluble
8 G H -0.7762 Soluble
9 G H -0.0592 Soluble
11 G H 0.5743 Aggregation-prone
12 L H 0.7942 Aggregation-prone
13 V H 0.0000 Buried
14 Q H -1.5223 Soluble
15 P H -1.6282 Soluble
16 G H -1.3626 Soluble
17 G H -1.0014 Soluble
18 S H -1.1399 Soluble
19 L H -1.0221 Soluble
20 R H -2.0950 Soluble
21 L H 0.0000 Buried
22 S H -0.3321 Soluble
23 C H 0.0000 Buried
24 A H -0.0530 Soluble
25 A H 0.0000 Buried
26 S H -0.9662 Soluble
27 G H -1.1884 Soluble
28 F H -0.4105 Soluble
29 T H -0.1438 Soluble
30 F H 0.0000 Buried
35 S H -0.8762 Soluble
36 S H -0.3597 Soluble
37 Y H 0.0709 Aggregation-prone
38 A H -0.3452 Soluble
39 M H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.6502 Soluble
45 A H -1.0224 Soluble
46 P H -1.0081 Soluble
47 G H -1.5053 Soluble
48 K H -2.2759 Soluble
49 G H -1.4312 Soluble
50 L H 0.0000 Buried
51 E H -1.0574 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 A H 0.0000 Buried
56 I H 0.0000 Buried
57 S H -0.7641 Soluble
58 G H -0.9537 Soluble
59 R H -1.9572 Soluble
62 G H -1.0215 Soluble
63 Y H 0.0440 Aggregation-prone
64 N H -1.1297 Soluble
65 A H -0.6323 Soluble
66 D H -1.0551 Soluble
67 Y H -1.0838 Soluble
68 A H -1.6558 Soluble
69 D H -2.7403 Soluble
70 S H -1.8116 Soluble
71 V H 0.0000 Buried
72 K H -2.6956 Soluble
74 G H -1.7358 Soluble
75 R H -1.2632 Soluble
76 F H 0.0000 Buried
77 T H -0.8552 Soluble
78 I H 0.0000 Buried
79 S H -0.5384 Soluble
80 R H -1.2139 Soluble
81 D H -1.6905 Soluble
82 N H -1.9575 Soluble
83 S H -1.5204 Soluble
84 K H -2.3113 Soluble
85 N H -1.6276 Soluble
86 T H -0.8504 Soluble
87 L H 0.0000 Buried
88 Y H -0.4684 Soluble
89 L H 0.0000 Buried
90 Q H -1.1381 Soluble
91 M H 0.0000 Buried
92 N H -1.3473 Soluble
93 S H -1.1506 Soluble
94 L H 0.0000 Buried
95 R H -2.1823 Soluble
96 A H -1.6699 Soluble
97 E H -2.2121 Soluble
98 D H 0.0000 Buried
99 T H -0.3806 Soluble
100 A H 0.0000 Buried
101 V H 0.7924 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 K H 0.0000 Buried
107 L H 0.1124 Aggregation-prone
108 E H -0.4321 Soluble
114 Y H -0.0595 Soluble
115 F H 0.0000 Buried
116 D H -0.2823 Soluble
117 Y H 0.2110 Aggregation-prone
118 W H 0.0416 Aggregation-prone
119 G H 0.0000 Buried
120 Q H -0.9979 Soluble
121 G H 0.0000 Buried
122 T H 0.6286 Aggregation-prone
123 L H 1.5437 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0797 Aggregation-prone
126 V H 0.0000 Buried
127 S H -0.8384 Soluble
128 S H -0.6834 Soluble
129 A H -0.5278 Soluble
130 S H -0.6143 Soluble
131 T H -0.8612 Soluble
132 K H -1.5677 Soluble
133 G H -1.5936 Soluble
134 P H 0.0000 Buried
135 S H -0.3624 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.1719 Soluble
139 L H -0.0944 Soluble
140 S H -0.3709 Soluble
141 T H -0.3619 Soluble
142 A H -0.1402 Soluble
143 A H 0.0318 Aggregation-prone
144 L H 0.0000 Buried
145 G H 0.0000 Buried
146 C H 0.0000 Buried
147 L H 0.0000 Buried
148 V H 0.0000 Buried
149 K H 0.0000 Buried
150 D H -0.7825 Soluble
151 Y H 0.0000 Buried
152 F H 0.0000 Buried
153 P H 0.0000 Buried
154 E H -1.0095 Soluble
155 P H -1.0715 Soluble
156 V H -0.8123 Soluble
157 T H -0.6125 Soluble
158 V H -0.3389 Soluble
159 S H -0.4840 Soluble
160 W H 0.0000 Buried
161 N H -1.0204 Soluble
162 S H -0.7744 Soluble
163 G H -0.5952 Soluble
164 A H -0.2581 Soluble
165 L H -0.0931 Soluble
166 T H -0.2052 Soluble
167 S H -0.4309 Soluble
168 G H -0.5415 Soluble
169 V H 0.0944 Aggregation-prone
170 H H 0.0000 Buried
171 T H 0.0852 Aggregation-prone
172 F H 0.0000 Buried
173 P H -0.3677 Soluble
174 A H 0.1324 Aggregation-prone
175 V H 0.5910 Aggregation-prone
176 L H 1.2585 Aggregation-prone
177 Q H 0.3170 Aggregation-prone
178 S H -0.0428 Soluble
179 S H -0.2695 Soluble
180 G H -0.0267 Soluble
181 L H -0.1369 Soluble
182 Y H 0.0000 Buried
183 S H 0.0000 Buried
184 L H 0.0000 Buried
185 S H 0.0000 Buried
186 S H 0.0000 Buried
187 V H 0.0000 Buried
188 V H 0.0000 Buried
189 T H -0.1335 Soluble
190 V H 0.0000 Buried
191 P H -0.3847 Soluble
192 S H -0.3794 Soluble
193 S H -0.5564 Soluble
194 S H 0.0000 Buried
195 L H -0.9106 Soluble
196 G H -1.2518 Soluble
197 T H -1.0495 Soluble
198 K H -2.0334 Soluble
199 T H -1.6654 Soluble
200 Y H 0.0000 Buried
201 T H -1.9739 Soluble
202 C H 0.0000 Buried
203 N H -1.6658 Soluble
204 V H 0.0000 Buried
205 D H -1.8695 Soluble
206 H H 0.0000 Buried
207 K H -2.7721 Soluble
208 P H -1.7743 Soluble
209 S H -1.9269 Soluble
210 N H -2.5816 Soluble
211 T H -2.0912 Soluble
212 K H -2.6442 Soluble
213 V H -1.5544 Soluble
214 D H -2.7609 Soluble
215 K H -2.3517 Soluble
216 R H -2.9479 Soluble
217 V H 0.0000 Buried
218 E H -2.5836 Soluble
219 S H -1.0787 Soluble
1 D L -2.2202 Soluble
2 I L -1.5301 Soluble
3 Q L -2.0913 Soluble
4 M L 0.0000 Buried
5 T L -1.3384 Soluble
6 Q L -0.9440 Soluble
7 S L -0.6325 Soluble
8 P L -0.5388 Soluble
9 S L -0.7650 Soluble
10 T L -0.6756 Soluble
11 L L -0.4461 Soluble
12 S L -0.7466 Soluble
13 A L 0.0000 Buried
14 S L -0.4896 Soluble
15 V L 0.2920 Aggregation-prone
16 G L -0.6791 Soluble
17 D L -1.5063 Soluble
18 R L -2.2182 Soluble
19 V L 0.0000 Buried
20 T L -0.4997 Soluble
21 I L 0.0000 Buried
22 T L -0.9077 Soluble
23 C L 0.0000 Buried
24 R L -2.9167 Soluble
25 A L 0.0000 Buried
26 S L -1.9778 Soluble
27 Q L -2.2113 Soluble
28 S L -1.4144 Soluble
29 I L 0.0000 Buried
36 S L -0.8338 Soluble
37 S L -0.7340 Soluble
38 W L -0.1948 Soluble
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -1.3285 Soluble
45 K L -1.7842 Soluble
46 P L -1.5101 Soluble
47 G L -1.6854 Soluble
48 K L -2.5766 Soluble
49 A L -1.5363 Soluble
50 P L 0.0000 Buried
51 K L -1.5112 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.1838 Soluble
56 K L -1.0530 Soluble
57 A L 0.0000 Buried
65 S L -0.5621 Soluble
66 S L -0.3273 Soluble
67 L L 0.0615 Aggregation-prone
68 E L -0.6557 Soluble
69 S L -0.4909 Soluble
70 G L -0.5418 Soluble
71 V L -0.3648 Soluble
72 P L -0.3321 Soluble
74 S L -0.4420 Soluble
75 R L -0.8450 Soluble
76 F L 0.0000 Buried
77 S L -0.3258 Soluble
78 G L -0.4006 Soluble
79 S L -0.8759 Soluble
80 G L -1.2787 Soluble
83 S L -1.2240 Soluble
84 G L -1.2943 Soluble
85 T L -2.0115 Soluble
86 D L -2.7526 Soluble
87 F L 0.0000 Buried
88 T L -0.8580 Soluble
89 L L 0.0000 Buried
90 T L -0.6201 Soluble
91 I L 0.0000 Buried
92 S L -1.3641 Soluble
93 S L -1.0813 Soluble
94 L L 0.0000 Buried
95 R L -1.0780 Soluble
96 P L -0.9431 Soluble
97 E L -1.9713 Soluble
98 D L 0.0000 Buried
99 F L -0.5702 Soluble
100 A L 0.0000 Buried
101 T L 0.0000 Buried
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L -0.0766 Soluble
108 N L -0.4894 Soluble
109 S L -0.2475 Soluble
114 Y L 0.1168 Aggregation-prone
115 P L -0.3569 Soluble
116 L L 0.0000 Buried
117 T L -0.5731 Soluble
118 F L -0.3094 Soluble
119 G L 0.0000 Buried
120 G L -1.1775 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.4487 Soluble
124 V L 0.0000 Buried
125 E L -0.9495 Soluble
126 I L -0.3266 Soluble
127 K L -1.3252 Soluble
128 R L -1.0348 Soluble
129 T L -0.0453 Soluble
130 V L 0.7913 Aggregation-prone
131 A L 0.2917 Aggregation-prone
132 A L -0.0313 Soluble
133 P L 0.0000 Buried
134 S L -0.1715 Soluble
135 V L 0.0000 Buried
136 F L 0.1007 Aggregation-prone
137 I L 0.1555 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.7031 Soluble
140 P L 0.0000 Buried
141 S L -1.6786 Soluble
142 D L -3.0911 Soluble
143 E L -3.2813 Soluble
144 Q L 0.0000 Buried
145 L L -2.3457 Soluble
146 K L -2.9803 Soluble
147 S L -1.8591 Soluble
148 G L -1.3759 Soluble
149 T L -1.1505 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.8773 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.7054 Soluble
162 R L -3.1281 Soluble
163 E L -3.2062 Soluble
164 A L -2.3482 Soluble
165 K L -2.5532 Soluble
166 V L -1.2659 Soluble
167 Q L -1.0987 Soluble
168 W L 0.0000 Buried
169 K L -0.9312 Soluble
170 V L 0.0000 Buried
171 D L -2.0355 Soluble
172 N L -1.5618 Soluble
173 A L -0.6276 Soluble
174 L L 0.1311 Aggregation-prone
175 Q L -0.4307 Soluble
176 S L -0.6439 Soluble
177 G L -0.8921 Soluble
178 N L -0.8298 Soluble
179 S L -1.0941 Soluble
180 Q L -1.1773 Soluble
181 E L -1.8233 Soluble
182 S L -0.7765 Soluble
183 V L -0.8367 Soluble
184 T L -1.1570 Soluble
185 E L -2.2810 Soluble
186 Q L -1.8414 Soluble
187 D L -1.8462 Soluble
188 S L -1.7069 Soluble
189 K L -2.2900 Soluble
190 D L -1.6247 Soluble
191 S L -1.6283 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.6170 Soluble
199 L L 0.0000 Buried
200 T L -0.2831 Soluble
201 L L -0.7263 Soluble
202 S L -1.1515 Soluble
203 K L -2.1410 Soluble
204 A L -1.8962 Soluble
205 D L -2.7426 Soluble
206 Y L 0.0000 Buried
207 E L -3.0110 Soluble
208 K L -3.3991 Soluble
209 H L -2.9497 Soluble
210 K L -3.0608 Soluble
211 V L -1.5550 Soluble
212 Y L 0.0000 Buried
213 A L -0.7973 Soluble
214 C L 0.0000 Buried
215 E L -1.2560 Soluble
216 V L 0.0000 Buried
217 T L -1.3029 Soluble
218 H L 0.0000 Buried
219 Q L -1.7335 Soluble
220 G L -0.3255 Soluble
221 L L -0.1225 Soluble
222 S L -0.4247 Soluble
223 S L -0.3942 Soluble
224 P L -0.6064 Soluble
225 V L -0.0560 Soluble
226 T L -0.5642 Soluble
227 K L -0.7304 Soluble
228 S L -0.7073 Soluble
229 F L -1.1394 Soluble
230 N L -2.2321 Soluble
231 R L -2.4922 Soluble
232 G L -1.9906 Soluble
233 E L -2.5673 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7917 1.9961 CSV PDB
4.5 -0.8369 1.9961 CSV PDB
5.0 -0.8902 1.9961 CSV PDB
5.5 -0.9415 1.9961 CSV PDB
6.0 -0.9791 1.9961 CSV PDB
6.5 -0.9936 1.9961 CSV PDB
7.0 -0.9839 1.9961 CSV PDB
7.5 -0.9574 1.9961 CSV PDB
8.0 -0.9213 1.9961 CSV PDB
8.5 -0.8783 1.9961 CSV PDB
9.0 -0.8283 1.9961 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH