Boserolimab / 8ds5

A4DAB053_8ds5_C_B | Source PDB: 8ds5 | Chains: C, B | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6878
Max Score
1.4955
Min Score
-3.7394
Total Score
-291.63
Score CDR
-0.5467
Score non-CDR
-0.7033

Calculation Parameters

Chain Sequence(s) EIQLVQSGAEVKKPGASVKVSCKASGYTFTNYGMNWVKQAPGQGLKWMGWINTNTGEPTYAEEFKGRFTFTLDTSISTAYMELSSLRSEDTAVYYCAREGDAMDYWGQGTTVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKEIVLTQSPATLSLSPGERATLSCSASSSVSYMHWYQQKPGQAPKRWIYDTSKLASGVPARFSGSGSGTDYSLTISSLEPEDFAVYYCQQWNSYPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) C (Heavy), B (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7394
Maximum Score 1.4955
Average Score -0.6878
Total Score -291.6336

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E C -2.0746 Soluble
2 I C -1.1864 Soluble
3 Q C -1.2942 Soluble
4 L C 0.0000 Buried
5 V C 0.3818 Aggregation-prone
6 Q C 0.0000 Buried
7 S C -0.5279 Soluble
8 G C -0.5675 Soluble
9 A C -0.2164 Soluble
11 E C -0.3053 Soluble
12 V C 0.1623 Aggregation-prone
13 K C -1.1904 Soluble
14 K C -2.1558 Soluble
15 P C -2.2021 Soluble
16 G C -1.5834 Soluble
17 A C -1.2014 Soluble
18 S C -1.3424 Soluble
19 V C 0.0000 Buried
20 K C -1.9412 Soluble
21 V C 0.0000 Buried
22 S C -0.6024 Soluble
23 C C 0.0000 Buried
24 K C -0.5352 Soluble
25 A C 0.0000 Buried
26 S C -0.7580 Soluble
27 G C -1.1442 Soluble
28 Y C -0.5440 Soluble
29 T C -0.4042 Soluble
30 F C 0.0000 Buried
35 T C -1.0950 Soluble
36 N C -1.4821 Soluble
37 Y C -0.7937 Soluble
38 G C -0.7488 Soluble
39 M C 0.0000 Buried
40 N C 0.0000 Buried
41 W C 0.0000 Buried
42 V C 0.0000 Buried
43 K C -0.7369 Soluble
44 Q C -0.8780 Soluble
45 A C -1.1245 Soluble
46 P C -1.0367 Soluble
47 G C -1.2059 Soluble
48 Q C -1.9581 Soluble
49 G C -1.4687 Soluble
50 L C 0.0000 Buried
51 K C -1.5461 Soluble
52 W C 0.0000 Buried
53 M C 0.0000 Buried
54 G C 0.0000 Buried
55 W C -0.1608 Soluble
56 I C 0.0000 Buried
57 N C -1.4999 Soluble
58 T C 0.0000 Buried
59 N C -1.9598 Soluble
62 T C -1.4011 Soluble
63 G C -1.6092 Soluble
64 E C -2.2355 Soluble
65 P C -1.0179 Soluble
66 T C -0.6686 Soluble
67 Y C -0.9544 Soluble
68 A C -1.7777 Soluble
69 E C -3.2865 Soluble
70 E C -3.2434 Soluble
71 F C 0.0000 Buried
72 K C -3.0251 Soluble
74 G C -1.9131 Soluble
75 R C -1.3759 Soluble
76 F C 0.0000 Buried
77 T C -0.8808 Soluble
78 F C 0.0000 Buried
79 T C -0.6780 Soluble
80 L C -0.5328 Soluble
81 D C -0.5376 Soluble
82 T C -0.3775 Soluble
83 S C 0.1628 Aggregation-prone
84 I C 0.7726 Aggregation-prone
85 S C 0.0153 Aggregation-prone
86 T C 0.0000 Buried
87 A C 0.0000 Buried
88 Y C -0.6260 Soluble
89 M C 0.0000 Buried
90 E C -1.5056 Soluble
91 L C 0.0000 Buried
92 S C -1.1489 Soluble
93 S C -1.2370 Soluble
94 L C 0.0000 Buried
95 R C -3.0882 Soluble
96 S C -2.3529 Soluble
97 E C -2.5736 Soluble
98 D C 0.0000 Buried
99 T C -0.9725 Soluble
100 A C 0.0000 Buried
101 V C 0.0515 Aggregation-prone
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 A C 0.0000 Buried
106 R C 0.0000 Buried
107 E C -0.7757 Soluble
108 G C -1.1325 Soluble
109 D C -1.8976 Soluble
114 A C 0.0000 Buried
115 M C 0.0000 Buried
116 D C -0.7712 Soluble
117 Y C -0.4260 Soluble
118 W C 0.0000 Buried
119 G C 0.0000 Buried
120 Q C -1.2613 Soluble
121 G C -0.6614 Soluble
122 T C 0.0000 Buried
123 T C -0.1811 Soluble
124 V C 0.0000 Buried
125 T C 0.0000 Buried
126 V C 0.0000 Buried
127 S C -1.2933 Soluble
128 S C -1.1674 Soluble
129 A C -0.5992 Soluble
130 S C -0.6684 Soluble
131 T C -0.6039 Soluble
132 K C -1.2869 Soluble
133 G C -1.3925 Soluble
134 P C 0.0000 Buried
135 S C -0.2982 Soluble
136 V C 0.0000 Buried
137 F C 0.0000 Buried
138 P C 0.0000 Buried
139 L C 0.0000 Buried
140 A C -1.0224 Soluble
141 P C 0.0000 Buried
142 S C -0.5446 Soluble
143 S C -0.3637 Soluble
144 G C -0.6384 Soluble
145 T C -0.5084 Soluble
146 A C 0.0000 Buried
147 A C 0.0000 Buried
148 L C 0.0000 Buried
149 G C 0.0000 Buried
150 C C 0.0000 Buried
151 L C 0.0000 Buried
152 V C 0.0000 Buried
153 K C 0.0000 Buried
154 D C -0.3466 Soluble
155 Y C 0.0000 Buried
156 F C 0.0000 Buried
157 P C 0.0000 Buried
158 E C -0.7085 Soluble
159 P C -1.0189 Soluble
160 V C -0.8648 Soluble
161 T C -0.6990 Soluble
162 V C -0.3431 Soluble
163 S C -0.3476 Soluble
164 W C 0.0000 Buried
165 N C -0.6205 Soluble
166 S C -0.5839 Soluble
167 G C -0.5669 Soluble
168 A C -0.2343 Soluble
169 L C 0.0207 Aggregation-prone
170 T C -0.1722 Soluble
171 S C -0.1821 Soluble
172 G C -0.2110 Soluble
173 V C 0.1878 Aggregation-prone
174 H C -0.3217 Soluble
175 T C 0.0148 Aggregation-prone
176 F C 0.0000 Buried
177 P C -0.3177 Soluble
178 A C 0.2369 Aggregation-prone
179 V C 0.7232 Aggregation-prone
180 L C 1.4955 Aggregation-prone
181 Q C 0.4961 Aggregation-prone
182 S C 0.0252 Aggregation-prone
183 S C -0.1313 Soluble
184 G C 0.1121 Aggregation-prone
185 L C 0.1713 Aggregation-prone
186 Y C 0.5773 Aggregation-prone
187 S C 0.0000 Buried
188 L C 0.0000 Buried
189 S C 0.0000 Buried
190 S C 0.0000 Buried
191 V C 0.0000 Buried
192 V C 0.0000 Buried
193 T C -0.1330 Soluble
194 V C 0.0000 Buried
195 P C -0.4894 Soluble
196 S C -0.5470 Soluble
197 S C -0.6076 Soluble
198 S C -0.5860 Soluble
199 L C -0.6367 Soluble
200 G C -0.8348 Soluble
201 T C -0.6953 Soluble
202 Q C -1.1076 Soluble
203 T C -0.8852 Soluble
204 Y C 0.0000 Buried
205 I C -0.7679 Soluble
206 C C 0.0000 Buried
207 N C -1.2706 Soluble
208 V C 0.0000 Buried
209 N C -2.0806 Soluble
210 H C 0.0000 Buried
211 K C -2.8254 Soluble
212 P C -1.5880 Soluble
213 S C -1.8699 Soluble
214 N C -2.6112 Soluble
215 T C -2.1234 Soluble
216 K C -2.6467 Soluble
217 V C -1.3380 Soluble
218 D C -1.9503 Soluble
219 K C -1.6953 Soluble
220 K C -1.9391 Soluble
221 V C 0.0000 Buried
222 E C -2.1789 Soluble
223 P C -1.8009 Soluble
224 K C -2.3582 Soluble
1 E B -1.3014 Soluble
2 I B 0.0573 Aggregation-prone
3 V B 1.1517 Aggregation-prone
4 L B 0.0000 Buried
5 T B -0.2065 Soluble
6 Q B 0.0000 Buried
7 S B -0.4980 Soluble
8 P B -0.2756 Soluble
9 A B -0.3421 Soluble
10 T B -0.1284 Soluble
11 L B -0.0791 Soluble
12 S B -0.4125 Soluble
13 L B -0.9515 Soluble
14 S B -1.4270 Soluble
15 P B -1.7285 Soluble
16 G B -1.7407 Soluble
17 E B -2.4526 Soluble
18 R B -2.5618 Soluble
19 A B 0.0000 Buried
20 T B -0.5635 Soluble
21 L B 0.0000 Buried
22 S B -0.6379 Soluble
23 C B 0.0000 Buried
24 S B -0.7268 Soluble
25 A B 0.0000 Buried
26 S B -0.2426 Soluble
27 S B -0.5543 Soluble
28 S B -0.9326 Soluble
29 V B 0.0000 Buried
37 S B 0.0198 Aggregation-prone
38 Y B 0.7266 Aggregation-prone
39 M B 0.0000 Buried
40 H B 0.0000 Buried
41 W B 0.0000 Buried
42 Y B 0.0000 Buried
43 Q B 0.0000 Buried
44 Q B 0.0000 Buried
45 K B -1.3918 Soluble
46 P B -1.3847 Soluble
47 G B -1.4211 Soluble
48 Q B -2.0228 Soluble
49 A B -1.3700 Soluble
50 P B 0.0000 Buried
51 K B -1.1463 Soluble
52 R B -0.7361 Soluble
53 W B -0.3455 Soluble
54 I B 0.0000 Buried
55 Y B -0.4514 Soluble
56 D B -0.3259 Soluble
57 T B -0.1699 Soluble
65 S B -0.6874 Soluble
66 K B -1.0240 Soluble
67 L B -0.2638 Soluble
68 A B -0.5594 Soluble
69 S B -0.4240 Soluble
70 G B -0.3998 Soluble
71 V B -0.1869 Soluble
72 P B -0.1292 Soluble
74 A B -0.0943 Soluble
75 R B -0.6469 Soluble
76 F B 0.0000 Buried
77 S B -0.4821 Soluble
78 G B -0.5550 Soluble
79 S B -0.7619 Soluble
80 G B -0.9071 Soluble
83 S B -0.9032 Soluble
84 G B -0.9616 Soluble
85 T B -1.3299 Soluble
86 D B -2.1582 Soluble
87 Y B 0.0000 Buried
88 S B -0.7240 Soluble
89 L B 0.0000 Buried
90 T B -0.6118 Soluble
91 I B 0.0000 Buried
92 S B -1.3280 Soluble
93 S B -1.6477 Soluble
94 L B 0.0000 Buried
95 E B -1.8348 Soluble
96 P B -1.5626 Soluble
97 E B -2.2342 Soluble
98 D B 0.0000 Buried
99 F B -0.5844 Soluble
100 A B 0.0000 Buried
101 V B -0.1346 Soluble
102 Y B 0.0000 Buried
103 Y B 0.0000 Buried
104 C B 0.0000 Buried
105 Q B 0.0000 Buried
106 Q B 0.0000 Buried
107 W B 0.3949 Aggregation-prone
108 N B -0.3981 Soluble
109 S B -0.1724 Soluble
114 Y B 0.5646 Aggregation-prone
115 P B -0.3681 Soluble
116 F B 0.0000 Buried
117 T B -0.1214 Soluble
118 F B 0.0000 Buried
119 G B 0.0000 Buried
120 Q B -1.4137 Soluble
121 G B 0.0000 Buried
122 T B 0.0000 Buried
123 K B -0.5295 Soluble
124 L B 0.0000 Buried
125 E B 0.0000 Buried
126 I B -0.7188 Soluble
127 K B -1.3632 Soluble
128 R B -0.9995 Soluble
129 T B -0.0826 Soluble
130 V B 0.4109 Aggregation-prone
131 A B 0.1436 Aggregation-prone
132 A B -0.1201 Soluble
133 P B 0.0000 Buried
134 S B -0.1564 Soluble
135 V B 0.0000 Buried
136 F B 0.1152 Aggregation-prone
137 I B 0.0668 Aggregation-prone
138 F B 0.0000 Buried
139 P B -0.8059 Soluble
140 P B -0.6728 Soluble
141 S B -1.4642 Soluble
142 D B -2.5998 Soluble
143 E B -1.9206 Soluble
144 Q B 0.0000 Buried
145 L B -1.9479 Soluble
146 K B -2.5010 Soluble
147 S B -1.5325 Soluble
148 G B -1.1773 Soluble
149 T B -0.9322 Soluble
150 A B 0.0000 Buried
151 S B 0.0000 Buried
152 V B 0.0000 Buried
153 V B 0.0000 Buried
154 C B 0.0000 Buried
155 L B 0.0000 Buried
156 L B 0.0000 Buried
157 N B 0.0000 Buried
158 N B -0.8503 Soluble
159 F B 0.0000 Buried
160 Y B 0.0000 Buried
161 P B -1.6315 Soluble
162 R B -2.7786 Soluble
163 E B -3.0899 Soluble
164 A B -2.2878 Soluble
165 K B -2.3615 Soluble
166 V B -1.2203 Soluble
167 Q B -0.8242 Soluble
168 W B 0.0000 Buried
169 K B -0.6869 Soluble
170 V B 0.0000 Buried
171 D B -1.9969 Soluble
172 N B -1.5542 Soluble
173 A B -0.2953 Soluble
174 L B 0.6517 Aggregation-prone
175 Q B -0.3597 Soluble
176 S B -0.7187 Soluble
177 G B -1.2324 Soluble
178 N B -1.5301 Soluble
179 S B -1.3610 Soluble
180 Q B -1.1632 Soluble
181 E B -1.6882 Soluble
182 S B -0.7218 Soluble
183 V B -0.7958 Soluble
184 T B -1.1844 Soluble
185 E B -2.2768 Soluble
186 Q B -1.8747 Soluble
187 D B -1.9675 Soluble
188 S B -1.9424 Soluble
189 K B -2.2172 Soluble
190 D B -1.6719 Soluble
191 S B -1.6942 Soluble
192 T B 0.0000 Buried
193 Y B 0.0000 Buried
194 S B 0.0000 Buried
195 L B 0.0000 Buried
196 S B 0.0000 Buried
197 S B 0.0000 Buried
198 T B 0.0000 Buried
199 L B 0.0000 Buried
200 T B -0.3925 Soluble
201 L B -0.7992 Soluble
202 S B -1.0730 Soluble
203 K B -2.1513 Soluble
204 A B -1.9157 Soluble
205 D B -2.5435 Soluble
206 Y B 0.0000 Buried
207 E B -3.7394 Soluble
208 K B -3.7136 Soluble
209 H B -3.1327 Soluble
210 K B -3.2621 Soluble
211 V B -1.6426 Soluble
212 Y B 0.0000 Buried
213 A B 0.0000 Buried
214 C B 0.0000 Buried
215 E B -0.8168 Soluble
216 V B 0.0000 Buried
217 T B -1.2476 Soluble
218 H B 0.0000 Buried
219 Q B -1.5322 Soluble
220 G B -0.4240 Soluble
221 L B -0.2449 Soluble
222 S B -0.4635 Soluble
223 S B -0.4219 Soluble
224 P B -0.5769 Soluble
225 V B 0.0193 Aggregation-prone
226 T B -0.4815 Soluble
227 K B -0.6851 Soluble
228 S B -0.6282 Soluble
229 F B -1.1461 Soluble
230 N B -2.2037 Soluble
231 R B -2.8022 Soluble
232 G B -2.2628 Soluble
233 E B -2.3961 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6643 1.8229 CSV PDB
4.5 -0.7097 1.7976 CSV PDB
5.0 -0.7641 1.7673 CSV PDB
5.5 -0.8162 1.7356 CSV PDB
6.0 -0.853 1.7057 CSV PDB
6.5 -0.8638 1.6805 CSV PDB
7.0 -0.8477 1.6609 CSV PDB
7.5 -0.813 1.6453 CSV PDB
8.0 -0.7682 1.632 CSV PDB
8.5 -0.7167 1.6213 CSV PDB
9.0 -0.66 1.614 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH