Cilgavimab / 7l7e

A4DAB064_7l7e_E_F | Source PDB: 7l7e | Chains: E, F | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7175
Max Score
1.5086
Min Score
-3.5254
Total Score
-325.01
Score CDR
-0.4819
Score non-CDR
-0.7555

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVKPGGSLRLSCAASGFTFRDVWMSWVRQAPGKGLEWVGRIKSKIDGGTTDYAAPVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTTAGSYYYDTVGPGLPEGKFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLMYWASTRESGVPDRFSGSGSGAEFTLTISSLQAEDVAIYYCQQYYSTLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNRGEC input.pdb
Selected Chain(s) E (Heavy), F (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5254
Maximum Score 1.5086
Average Score -0.7175
Total Score -325.0084

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E E -2.5484 Soluble
2 V E 0.0000 Buried
3 Q E -1.4872 Soluble
4 L E 0.0000 Buried
5 V E 0.4702 Aggregation-prone
6 E E 0.0000 Buried
7 S E -0.4906 Soluble
8 G E -0.8629 Soluble
9 G E -0.5508 Soluble
11 G E -0.1913 Soluble
12 L E 0.0247 Aggregation-prone
13 V E -0.7809 Soluble
14 K E -2.0363 Soluble
15 P E -1.8895 Soluble
16 G E -1.5206 Soluble
17 G E -1.2609 Soluble
18 S E -1.3193 Soluble
19 L E -1.1371 Soluble
20 R E -2.1120 Soluble
21 L E 0.0000 Buried
22 S E -0.5043 Soluble
23 C E 0.0000 Buried
24 A E -0.2720 Soluble
25 A E 0.0000 Buried
26 S E -1.1710 Soluble
27 G E -1.5186 Soluble
28 F E -0.8788 Soluble
29 T E -0.6206 Soluble
30 F E 0.0000 Buried
35 R E -2.1091 Soluble
36 D E -1.1362 Soluble
37 V E 0.0000 Buried
38 W E 0.0000 Buried
39 M E 0.0000 Buried
40 S E 0.0000 Buried
41 W E 0.0000 Buried
42 V E 0.0000 Buried
43 R E 0.0000 Buried
44 Q E -0.7949 Soluble
45 A E -1.1864 Soluble
46 P E -0.9973 Soluble
47 G E -1.4919 Soluble
48 K E -2.2581 Soluble
49 G E -1.4014 Soluble
50 L E 0.0000 Buried
51 E E -0.9915 Soluble
52 W E 0.0000 Buried
53 V E 0.0000 Buried
54 G E 0.0000 Buried
55 R E -0.4750 Soluble
56 I E 0.0000 Buried
57 K E -1.1287 Soluble
58 S E 0.0000 Buried
59 K E -1.6489 Soluble
60 I E 0.3165 Aggregation-prone
61 D E -0.5295 Soluble
62 G E -0.8769 Soluble
63 G E -1.0667 Soluble
64 T E -0.9510 Soluble
65 T E -0.5942 Soluble
66 D E -0.9840 Soluble
67 Y E -0.8892 Soluble
68 A E -1.0551 Soluble
69 A E -1.0738 Soluble
70 P E -0.9882 Soluble
71 V E 0.0000 Buried
72 K E -2.1017 Soluble
74 G E -1.4944 Soluble
75 R E -1.2964 Soluble
76 F E 0.0000 Buried
77 T E -0.9633 Soluble
78 I E 0.0000 Buried
79 S E -0.3991 Soluble
80 R E -1.2406 Soluble
81 D E -1.4472 Soluble
82 D E 0.0000 Buried
83 S E -1.5468 Soluble
84 K E -2.1855 Soluble
85 N E -1.7861 Soluble
86 T E -1.0217 Soluble
87 L E 0.0000 Buried
88 Y E -0.5668 Soluble
89 L E 0.0000 Buried
90 Q E -1.3944 Soluble
91 M E 0.0000 Buried
92 N E -1.3219 Soluble
93 S E -1.2476 Soluble
94 L E 0.0000 Buried
95 K E -2.4365 Soluble
96 T E -1.9196 Soluble
97 E E -2.3201 Soluble
98 D E 0.0000 Buried
99 T E -0.7574 Soluble
100 A E 0.0000 Buried
101 V E 0.1497 Aggregation-prone
102 Y E 0.0000 Buried
103 Y E 0.0000 Buried
104 C E 0.0000 Buried
105 T E 0.0000 Buried
106 T E 0.0000 Buried
107 A E 0.0000 Buried
108 G E 0.0000 Buried
109 S E 0.0000 Buried
110 Y E 0.5489 Aggregation-prone
111 Y E 0.6788 Aggregation-prone
111A Y E 0.5948 Aggregation-prone
111B D E 0.3081 Aggregation-prone
111C T E 0.3245 Aggregation-prone
111D V E 0.2804 Aggregation-prone
112E G E -0.2677 Soluble
112D P E -0.5105 Soluble
112C G E -0.8808 Soluble
112B L E -0.8062 Soluble
112A P E -1.5629 Soluble
112 E E -2.4180 Soluble
113 G E -1.5271 Soluble
114 K E -1.0863 Soluble
115 F E -0.0527 Soluble
116 D E 0.0000 Buried
117 Y E -0.2350 Soluble
118 W E -0.3979 Soluble
119 G E 0.0000 Buried
120 Q E -1.3652 Soluble
121 G E -0.5699 Soluble
122 T E -0.0966 Soluble
123 L E 0.1688 Aggregation-prone
124 V E 0.0000 Buried
125 T E 0.0000 Buried
126 V E 0.0000 Buried
127 S E -0.9241 Soluble
128 S E -0.8532 Soluble
129 A E -0.5306 Soluble
130 S E -0.5922 Soluble
131 T E -0.6965 Soluble
132 K E -1.2313 Soluble
133 G E -1.4462 Soluble
134 P E -0.6647 Soluble
135 S E -0.4042 Soluble
136 V E 0.0000 Buried
137 F E 0.0000 Buried
138 P E -1.0800 Soluble
139 L E 0.0000 Buried
140 A E -1.3698 Soluble
141 P E 0.0000 Buried
142 S E -0.9437 Soluble
143 S E -0.6994 Soluble
144 K E -0.7959 Soluble
145 S E 0.0000 Buried
146 T E -0.5807 Soluble
147 S E -0.7296 Soluble
148 G E -0.8460 Soluble
149 G E -0.9007 Soluble
150 T E -0.6500 Soluble
151 A E 0.0000 Buried
152 A E 0.0000 Buried
153 L E 0.0000 Buried
154 G E 0.0000 Buried
155 C E 0.0000 Buried
156 L E 0.0000 Buried
157 V E 0.0000 Buried
158 K E 0.0000 Buried
159 D E -0.3241 Soluble
160 Y E 0.0000 Buried
161 F E -0.1173 Soluble
162 P E 0.0000 Buried
163 E E -0.3072 Soluble
164 P E -0.7175 Soluble
165 V E -0.7585 Soluble
166 T E -0.7356 Soluble
167 V E -0.2589 Soluble
168 S E -0.4260 Soluble
169 W E 0.0000 Buried
170 N E -0.7541 Soluble
171 S E -0.6105 Soluble
172 G E -0.3641 Soluble
173 A E -0.1774 Soluble
174 L E 0.0361 Aggregation-prone
175 T E -0.1945 Soluble
176 S E -0.2564 Soluble
177 G E -0.3053 Soluble
178 V E 0.0144 Aggregation-prone
179 H E -0.4169 Soluble
180 T E -0.2017 Soluble
181 F E 0.0000 Buried
182 P E -0.4088 Soluble
183 A E 0.3242 Aggregation-prone
184 V E 0.7122 Aggregation-prone
185 L E 1.5086 Aggregation-prone
186 Q E 0.4104 Aggregation-prone
187 S E -0.0054 Soluble
188 S E -0.2075 Soluble
189 G E 0.0632 Aggregation-prone
190 L E 0.2685 Aggregation-prone
191 Y E 0.6202 Aggregation-prone
192 S E 0.4448 Aggregation-prone
193 L E 0.1930 Aggregation-prone
194 S E 0.0000 Buried
195 S E 0.0000 Buried
196 V E 0.0000 Buried
197 V E 0.0000 Buried
198 T E -0.2503 Soluble
199 V E 0.0000 Buried
200 P E -0.6840 Soluble
201 S E -0.7210 Soluble
202 S E -0.6168 Soluble
203 S E -0.6780 Soluble
204 L E -0.8652 Soluble
205 G E -1.0232 Soluble
206 T E -0.8666 Soluble
207 Q E -1.5319 Soluble
208 T E -1.2702 Soluble
209 Y E 0.0000 Buried
210 I E -1.3274 Soluble
211 C E 0.0000 Buried
212 N E -1.6075 Soluble
213 V E 0.0000 Buried
214 N E -2.4415 Soluble
215 H E 0.0000 Buried
216 K E -2.7920 Soluble
217 P E -1.5438 Soluble
218 S E -1.8105 Soluble
219 N E -2.6216 Soluble
220 T E -2.2010 Soluble
221 K E -2.8749 Soluble
222 V E -1.7733 Soluble
223 D E -2.5914 Soluble
224 K E -1.9578 Soluble
225 K E -2.5429 Soluble
226 V E 0.0000 Buried
227 E E -2.8770 Soluble
228 P E -2.1153 Soluble
229 K E -2.1882 Soluble
230 S E -1.2011 Soluble
231 C E -0.9679 Soluble
1 D F -1.4686 Soluble
2 I F 0.0000 Buried
3 V F 0.6298 Aggregation-prone
4 M F 0.0000 Buried
5 T F -0.9249 Soluble
6 Q F 0.0000 Buried
7 S F -1.4227 Soluble
8 P F -1.4934 Soluble
9 D F -2.3435 Soluble
10 S F -1.4211 Soluble
11 L F -0.6661 Soluble
12 A F -0.5974 Soluble
13 V F -0.7608 Soluble
14 S F -0.6644 Soluble
15 L F 0.2614 Aggregation-prone
16 G F -0.7685 Soluble
17 E F -2.0909 Soluble
18 R F -2.5027 Soluble
19 A F 0.0000 Buried
20 T F -0.6956 Soluble
21 I F 0.0000 Buried
22 N F -1.8801 Soluble
23 C F 0.0000 Buried
24 K F -2.4175 Soluble
25 S F 0.0000 Buried
26 S F -0.8741 Soluble
27 Q F -1.1536 Soluble
28 S F -0.7900 Soluble
29 V F 0.0000 Buried
30 L F -0.1262 Soluble
31 Y F -0.1211 Soluble
32 S F -0.7690 Soluble
33 S F -0.9917 Soluble
34 N F -1.8072 Soluble
35 N F -1.9540 Soluble
36 K F -1.3899 Soluble
37 N F -0.5604 Soluble
38 Y F 0.0000 Buried
39 L F 0.0000 Buried
40 A F 0.0000 Buried
41 W F 0.0000 Buried
42 Y F 0.0000 Buried
43 Q F -0.7218 Soluble
44 Q F 0.0000 Buried
45 K F -1.5633 Soluble
46 P F -1.4188 Soluble
47 G F -1.6051 Soluble
48 Q F -1.9546 Soluble
49 P F -1.3671 Soluble
50 P F 0.0000 Buried
51 K F -1.3107 Soluble
52 L F 0.0000 Buried
53 L F 0.0000 Buried
54 M F 0.0000 Buried
55 Y F -0.1157 Soluble
56 W F -0.1485 Soluble
57 A F 0.0000 Buried
65 S F -0.5890 Soluble
66 T F -0.6502 Soluble
67 R F -1.5950 Soluble
68 E F 0.0000 Buried
69 S F -0.9010 Soluble
70 G F -1.0349 Soluble
71 V F 0.0000 Buried
72 P F -1.4101 Soluble
74 D F -2.2664 Soluble
75 R F -1.6039 Soluble
76 F F 0.0000 Buried
77 S F -0.9328 Soluble
78 G F 0.0000 Buried
79 S F -0.7644 Soluble
80 G F -1.3656 Soluble
83 S F -1.1293 Soluble
84 G F -1.0664 Soluble
85 A F -1.7165 Soluble
86 E F -2.8799 Soluble
87 F F 0.0000 Buried
88 T F -1.1738 Soluble
89 L F 0.0000 Buried
90 T F -0.6767 Soluble
91 I F 0.0000 Buried
92 S F -1.7124 Soluble
93 S F -1.5123 Soluble
94 L F 0.0000 Buried
95 Q F -1.2088 Soluble
96 A F 0.0000 Buried
97 E F -2.2646 Soluble
98 D F 0.0000 Buried
99 V F -1.0439 Soluble
100 A F 0.0000 Buried
101 I F -0.5585 Soluble
102 Y F 0.0000 Buried
103 Y F 0.0000 Buried
104 C F 0.0000 Buried
105 Q F 0.0000 Buried
106 Q F 0.0000 Buried
107 Y F 0.0000 Buried
108 Y F 0.2128 Aggregation-prone
114 S F -0.2955 Soluble
115 T F -0.3948 Soluble
116 L F 0.0000 Buried
117 T F -0.1294 Soluble
118 F F 0.0000 Buried
119 G F 0.0000 Buried
120 G F -1.1163 Soluble
121 G F -1.1415 Soluble
122 T F 0.0000 Buried
123 K F -1.4358 Soluble
124 V F 0.0000 Buried
125 E F -0.7073 Soluble
126 I F 0.0000 Buried
127 K F -0.9771 Soluble
128 R F -0.5946 Soluble
129 T F 0.0483 Aggregation-prone
130 V F 0.5190 Aggregation-prone
131 A F -0.0296 Soluble
132 A F -0.3356 Soluble
133 P F 0.0000 Buried
134 S F -0.3338 Soluble
135 V F 0.0000 Buried
136 F F 0.0000 Buried
137 I F 0.0000 Buried
138 F F 0.0000 Buried
139 P F -0.4598 Soluble
140 P F -0.6041 Soluble
141 S F -1.6934 Soluble
142 D F -2.7740 Soluble
143 E F -2.6289 Soluble
144 Q F 0.0000 Buried
145 L F -2.1390 Soluble
146 K F -2.7509 Soluble
147 S F -1.6843 Soluble
148 G F -1.2963 Soluble
149 T F -1.2060 Soluble
150 A F 0.0000 Buried
151 S F 0.0000 Buried
152 V F 0.0000 Buried
153 V F 0.0000 Buried
154 C F 0.0000 Buried
155 L F 0.0000 Buried
156 L F 0.0000 Buried
157 N F -0.5726 Soluble
158 N F -1.0301 Soluble
159 F F 0.0000 Buried
160 Y F 0.0000 Buried
161 P F -1.3849 Soluble
162 R F -2.2158 Soluble
163 E F -2.8479 Soluble
164 A F -2.1192 Soluble
165 K F -2.3737 Soluble
166 V F -1.3308 Soluble
167 Q F -0.7819 Soluble
168 W F 0.0000 Buried
169 K F -0.7340 Soluble
170 V F 0.0000 Buried
171 D F -1.8185 Soluble
172 N F -1.5666 Soluble
173 A F -0.4295 Soluble
174 L F 0.3385 Aggregation-prone
175 Q F -0.3311 Soluble
176 S F -0.5288 Soluble
177 G F -0.9049 Soluble
178 N F -0.8370 Soluble
179 S F -1.1288 Soluble
180 Q F -1.2461 Soluble
181 E F -1.8547 Soluble
182 S F -0.7599 Soluble
183 V F -0.6129 Soluble
184 T F -1.0956 Soluble
185 E F -2.1035 Soluble
186 Q F 0.0000 Buried
187 D F -2.1982 Soluble
188 S F -2.3067 Soluble
189 K F -2.6103 Soluble
190 D F -1.8913 Soluble
191 S F 0.0000 Buried
192 T F 0.0000 Buried
193 Y F 0.0000 Buried
194 S F 0.0000 Buried
195 L F 0.0000 Buried
196 S F 0.0000 Buried
197 S F 0.0000 Buried
198 T F -0.6420 Soluble
199 L F 0.0000 Buried
200 T F -0.2957 Soluble
201 L F -0.6934 Soluble
202 S F -1.0904 Soluble
203 K F -2.0554 Soluble
204 A F -1.8624 Soluble
205 D F -2.6286 Soluble
206 Y F 0.0000 Buried
207 E F -3.3443 Soluble
208 K F -3.5254 Soluble
209 H F -2.7411 Soluble
210 K F -2.7337 Soluble
211 V F -1.1942 Soluble
212 Y F 0.0000 Buried
213 A F 0.0000 Buried
214 C F 0.0000 Buried
215 E F -0.7245 Soluble
216 V F 0.0000 Buried
217 T F -1.3999 Soluble
218 H F 0.0000 Buried
219 Q F -1.9232 Soluble
220 G F -0.7489 Soluble
221 L F -1.0068 Soluble
222 R F -2.0512 Soluble
223 S F -1.1906 Soluble
224 P F -0.8579 Soluble
225 V F -0.1090 Soluble
226 T F -0.3324 Soluble
227 K F -0.5888 Soluble
228 S F -0.3824 Soluble
229 F F 0.0000 Buried
230 N F -1.3521 Soluble
231 R F -1.9037 Soluble
232 G F -1.5914 Soluble
233 E F -1.9857 Soluble
234 C F -0.8296 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7119 2.2166 CSV PDB
4.5 -0.7558 2.2167 CSV PDB
5.0 -0.8074 2.2168 CSV PDB
5.5 -0.8562 2.2173 CSV PDB
6.0 -0.8899 2.2186 CSV PDB
6.5 -0.8981 2.2219 CSV PDB
7.0 -0.8801 2.2282 CSV PDB
7.5 -0.8443 2.2372 CSV PDB
8.0 -0.7986 2.2477 CSV PDB
8.5 -0.746 2.2587 CSV PDB
9.0 -0.6871 2.2698 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH