Amubarvimab / 7cdi

A4DAB014_7cdi_H_L | Source PDB: 7cdi | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.703
Max Score
1.9901
Min Score
-3.719
Total Score
-297.35
Score CDR
-0.0662
Score non-CDR
-0.7769

Calculation Parameters

Chain Sequence(s) VQLVESGGGLVQPGGSLRLSCAASGITVSSNYMNWVRQAPGKGLEWVSLIYSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYHCARDLVVYGMDVWGQGTTVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.719
Maximum Score 1.9901
Average Score -0.703
Total Score -297.3512

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 0.9650 Aggregation-prone
3 Q H -0.3405 Soluble
4 L H 0.0000 Buried
5 V H 0.3641 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.4438 Soluble
8 G H -0.9046 Soluble
9 G H -0.4840 Soluble
11 G H 0.0279 Aggregation-prone
12 L H 0.7178 Aggregation-prone
13 V H 0.0000 Buried
14 Q H -1.5313 Soluble
15 P H -1.8036 Soluble
16 G H -1.5531 Soluble
17 G H -1.0893 Soluble
18 S H -1.1957 Soluble
19 L H -1.0895 Soluble
20 R H -2.1520 Soluble
21 L H 0.0000 Buried
22 S H -0.5519 Soluble
23 C H 0.0000 Buried
24 A H -0.3483 Soluble
25 A H 0.0000 Buried
26 S H -0.2064 Soluble
27 G H -0.1253 Soluble
28 I H 0.0000 Buried
29 T H -0.8132 Soluble
30 V H 0.0000 Buried
35 S H -0.8757 Soluble
36 S H -0.5177 Soluble
37 N H -0.1715 Soluble
38 Y H 0.2483 Aggregation-prone
39 M H 0.0000 Buried
40 N H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.8468 Soluble
45 A H -1.2325 Soluble
46 P H -0.9911 Soluble
47 G H -1.4659 Soluble
48 K H -2.4231 Soluble
49 G H -1.6856 Soluble
50 L H 0.0000 Buried
51 E H -1.3791 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 L H 0.0000 Buried
56 I H 0.0000 Buried
57 Y H 0.0674 Aggregation-prone
58 S H -0.3398 Soluble
59 G H -0.5991 Soluble
63 G H -0.5091 Soluble
64 S H -0.1678 Soluble
65 T H 0.1517 Aggregation-prone
66 Y H 0.1029 Aggregation-prone
67 Y H -0.6067 Soluble
68 A H -1.3485 Soluble
69 D H -2.4214 Soluble
70 S H -1.8107 Soluble
71 V H 0.0000 Buried
72 K H -2.4801 Soluble
74 G H -1.6588 Soluble
75 R H 0.0000 Buried
76 F H 0.0000 Buried
77 T H -0.7571 Soluble
78 I H 0.0000 Buried
79 S H -0.6399 Soluble
80 R H -1.3634 Soluble
81 D H -1.9263 Soluble
82 N H -2.3739 Soluble
83 S H -1.9242 Soluble
84 K H -2.5302 Soluble
85 N H -1.9103 Soluble
86 T H 0.0000 Buried
87 L H 0.0000 Buried
88 Y H -0.7251 Soluble
89 L H 0.0000 Buried
90 Q H -1.3114 Soluble
91 M H 0.0000 Buried
92 N H -1.4698 Soluble
93 S H -1.3080 Soluble
94 L H 0.0000 Buried
95 R H -2.7092 Soluble
96 A H -1.9227 Soluble
97 E H -2.3621 Soluble
98 D H 0.0000 Buried
99 T H -0.7652 Soluble
100 A H 0.0000 Buried
101 V H 0.1879 Aggregation-prone
102 Y H 0.0000 Buried
103 H H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H -0.1314 Soluble
107 D H 0.0000 Buried
108 L H 1.2812 Aggregation-prone
109 V H 1.4607 Aggregation-prone
110 V H 1.9901 Aggregation-prone
113 Y H 1.6330 Aggregation-prone
114 G H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.5009 Soluble
117 V H -0.1875 Soluble
118 W H -0.4390 Soluble
119 G H 0.0000 Buried
120 Q H -1.3824 Soluble
121 G H 0.0000 Buried
122 T H -0.2110 Soluble
123 T H -0.0218 Soluble
124 V H 0.0000 Buried
125 T H -0.2051 Soluble
126 V H 0.0000 Buried
127 S H -0.9425 Soluble
128 S H -0.8068 Soluble
129 A H -0.6872 Soluble
130 S H -0.8336 Soluble
131 T H -1.2565 Soluble
132 K H -1.9948 Soluble
133 G H -1.9171 Soluble
134 P H 0.0000 Buried
135 S H -0.5584 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.1910 Soluble
139 L H 0.0000 Buried
140 A H -0.8241 Soluble
141 P H -0.5048 Soluble
142 S H -0.3903 Soluble
144 T H -0.2881 Soluble
145 A H -0.1859 Soluble
146 A H 0.0000 Buried
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.0000 Buried
151 V H 0.0000 Buried
152 K H 0.0000 Buried
153 D H -0.6613 Soluble
154 Y H 0.0000 Buried
155 F H 0.0000 Buried
156 P H -1.2670 Soluble
157 E H -1.8807 Soluble
158 P H -1.5682 Soluble
159 V H -1.1993 Soluble
160 T H -0.9122 Soluble
161 V H -0.3145 Soluble
162 S H -0.4433 Soluble
163 W H 0.0000 Buried
164 N H -0.7726 Soluble
165 S H -0.6667 Soluble
166 G H -0.5896 Soluble
167 A H -0.2510 Soluble
168 L H -0.0123 Soluble
169 T H -0.1800 Soluble
170 S H -0.1949 Soluble
171 G H -0.2333 Soluble
172 V H 0.1315 Aggregation-prone
173 H H -0.2726 Soluble
174 T H 0.0617 Aggregation-prone
175 F H 0.0000 Buried
176 P H -0.2159 Soluble
177 A H 0.0331 Aggregation-prone
178 V H 0.2815 Aggregation-prone
179 L H 0.6031 Aggregation-prone
180 Q H -0.0225 Soluble
181 S H -0.1823 Soluble
182 S H -0.2661 Soluble
183 G H -0.0396 Soluble
184 L H -0.3009 Soluble
185 Y H -0.0790 Soluble
186 S H 0.0000 Buried
187 L H 0.0000 Buried
188 S H 0.0000 Buried
189 S H 0.0000 Buried
190 V H 0.0000 Buried
191 V H 0.0000 Buried
192 T H -0.1727 Soluble
193 V H 0.0000 Buried
194 P H -0.4196 Soluble
195 S H -0.4800 Soluble
196 S H -0.5804 Soluble
197 S H -0.6517 Soluble
198 L H -0.8613 Soluble
199 G H -1.0529 Soluble
200 T H -0.7670 Soluble
201 Q H -1.2802 Soluble
202 T H -1.1162 Soluble
203 Y H 0.0000 Buried
204 I H -1.2373 Soluble
205 C H 0.0000 Buried
206 N H -1.5460 Soluble
207 V H 0.0000 Buried
208 N H -2.5304 Soluble
209 H H 0.0000 Buried
210 K H -3.0379 Soluble
211 P H -2.0391 Soluble
212 S H -2.1069 Soluble
213 N H -2.7067 Soluble
214 T H -2.3632 Soluble
215 K H -2.9682 Soluble
216 V H -1.7462 Soluble
217 D H -2.4086 Soluble
218 K H -2.1909 Soluble
219 K H -2.4160 Soluble
220 V H 0.0000 Buried
221 E H -2.4974 Soluble
222 P H -1.2411 Soluble
1 E L -1.6249 Soluble
2 I L -0.4159 Soluble
3 V L 0.8157 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.5675 Soluble
6 Q L 0.0000 Buried
7 S L -0.7235 Soluble
8 P L -0.4499 Soluble
9 G L -0.8254 Soluble
10 T L -0.4898 Soluble
11 L L -0.1623 Soluble
12 S L -0.4185 Soluble
13 L L -1.0431 Soluble
14 S L -1.6330 Soluble
15 P L -2.1857 Soluble
16 G L -2.6501 Soluble
17 E L -3.4054 Soluble
18 R L -3.3508 Soluble
19 A L 0.0000 Buried
20 T L -0.6943 Soluble
21 L L 0.0000 Buried
22 S L -0.7837 Soluble
23 C L 0.0000 Buried
24 R L -1.7584 Soluble
25 A L -1.0792 Soluble
26 S L -0.8725 Soluble
27 Q L -1.6324 Soluble
28 S L -1.1826 Soluble
29 V L -0.7222 Soluble
30 S L -0.2996 Soluble
36 S L -0.1325 Soluble
37 S L 0.5163 Aggregation-prone
38 Y L 0.9903 Aggregation-prone
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -0.9432 Soluble
45 K L -1.4223 Soluble
46 P L -1.2198 Soluble
47 G L -1.4538 Soluble
48 Q L -2.0311 Soluble
49 A L -1.3241 Soluble
50 P L 0.0000 Buried
51 R L -1.2325 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.3985 Aggregation-prone
56 G L 0.3880 Aggregation-prone
57 A L 0.0000 Buried
65 S L -0.7769 Soluble
66 S L -0.7371 Soluble
67 R L -1.7457 Soluble
68 A L 0.0000 Buried
69 T L -0.7046 Soluble
70 G L -0.8509 Soluble
71 I L -1.0280 Soluble
72 P L -1.3250 Soluble
74 D L -2.4298 Soluble
75 R L -2.1769 Soluble
76 F L 0.0000 Buried
77 S L -0.9851 Soluble
78 G L -0.6253 Soluble
79 S L -0.7529 Soluble
80 G L -1.1943 Soluble
83 S L -1.1201 Soluble
84 G L -1.1894 Soluble
85 T L -1.6951 Soluble
86 D L -2.2741 Soluble
87 F L 0.0000 Buried
88 T L -0.7773 Soluble
89 L L 0.0000 Buried
90 T L -0.8221 Soluble
91 I L 0.0000 Buried
92 S L -2.5911 Soluble
93 R L -3.7190 Soluble
94 L L 0.0000 Buried
95 E L -2.6093 Soluble
96 P L -1.6369 Soluble
97 E L -2.3008 Soluble
98 D L 0.0000 Buried
99 F L -0.6081 Soluble
100 A L 0.0000 Buried
101 V L -0.2520 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.0000 Buried
108 G L -0.8401 Soluble
114 S L -0.5571 Soluble
115 S L -0.2789 Soluble
116 P L 0.0000 Buried
117 T L -0.2804 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.5715 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -0.6752 Soluble
124 L L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.4456 Soluble
127 K L -1.5039 Soluble
128 R L -1.0835 Soluble
129 T L -0.2429 Soluble
130 V L 0.2503 Aggregation-prone
131 A L -0.0219 Soluble
132 A L -0.1575 Soluble
133 P L 0.0000 Buried
134 S L -0.1126 Soluble
135 V L 0.0000 Buried
136 F L 0.1546 Aggregation-prone
137 I L 0.1001 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.4833 Soluble
140 P L -0.8670 Soluble
141 S L -1.7085 Soluble
142 D L -3.0549 Soluble
143 E L -3.2671 Soluble
144 Q L 0.0000 Buried
145 L L -2.4005 Soluble
146 K L -2.9272 Soluble
147 S L -1.8645 Soluble
148 G L -1.5029 Soluble
149 T L -1.1259 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.8177 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.4191 Soluble
162 R L -2.2408 Soluble
163 E L -2.8626 Soluble
164 A L -2.1730 Soluble
165 K L -2.2359 Soluble
166 V L -1.0003 Soluble
167 Q L -0.5591 Soluble
168 W L 0.0000 Buried
169 K L -0.4450 Soluble
170 V L 0.0000 Buried
171 D L -1.6615 Soluble
172 N L -1.3714 Soluble
173 A L -0.2286 Soluble
174 L L 0.7277 Aggregation-prone
175 Q L -0.1878 Soluble
176 S L -0.3689 Soluble
177 G L -0.9787 Soluble
178 N L -0.9190 Soluble
179 S L -1.2228 Soluble
180 Q L -1.6508 Soluble
181 E L -1.3493 Soluble
182 S L -0.3979 Soluble
183 V L -0.1511 Soluble
184 T L -0.9314 Soluble
185 E L -2.0988 Soluble
186 Q L -1.6966 Soluble
187 D L -1.9506 Soluble
188 S L -1.6739 Soluble
189 K L -2.2265 Soluble
190 D L -1.6838 Soluble
191 S L -1.6625 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.6368 Soluble
199 L L 0.0000 Buried
200 T L -0.4034 Soluble
201 L L -0.6571 Soluble
202 S L -1.3286 Soluble
203 K L -2.3556 Soluble
204 A L -1.9972 Soluble
205 D L -2.6252 Soluble
206 Y L 0.0000 Buried
207 E L -3.6137 Soluble
208 K L -3.5951 Soluble
209 H L -2.6443 Soluble
210 K L -2.5016 Soluble
211 V L -0.9332 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.6716 Soluble
216 V L 0.0000 Buried
217 T L -1.2211 Soluble
218 H L 0.0000 Buried
219 Q L -1.5261 Soluble
220 G L -0.5052 Soluble
221 L L -0.2899 Soluble
222 S L -0.4859 Soluble
223 S L -0.4135 Soluble
224 P L -0.5264 Soluble
225 V L 0.0179 Aggregation-prone
226 T L -0.4001 Soluble
227 K L -0.5464 Soluble
228 S L -0.3916 Soluble
229 F L -0.6402 Soluble
230 N L -1.5012 Soluble
231 R L -2.0174 Soluble
232 G L -1.8002 Soluble
233 E L -2.0323 Soluble
234 C L -0.3963 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7034 1.7718 CSV PDB
4.5 -0.7498 1.7718 CSV PDB
5.0 -0.8043 1.7718 CSV PDB
5.5 -0.857 1.7718 CSV PDB
6.0 -0.8964 1.7718 CSV PDB
6.5 -0.913 1.7718 CSV PDB
7.0 -0.9059 1.7717 CSV PDB
7.5 -0.8828 1.7716 CSV PDB
8.0 -0.8505 1.7711 CSV PDB
8.5 -0.8114 1.7698 CSV PDB
9.0 -0.766 1.7654 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH