Amubarvimab

A4DAB014 | Phase-II/III
SARS-CoV-2 Spike RBD
G1 / None
Brii Biosciences
Phase-II/III
Whole mAb
BRII-196 BRII196
—
Avg A4D Score
-0.6889
Score Range
-0.7 to -0.67
Structures
7
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB014_8gx9_I_L 8gx9 100% -0.6955 6.5 4.0 -0.0532 -0.77
A4DAB014_7e8m_H_L 7e8m 99% -0.6793 6.5 4.0 -0.0723 -0.7498
A4DAB014_7x2k_H_L 7x2k 100% -0.6771 6.5 4.0 -0.0279 -0.7525
A4DAB014_7swo_H_L 7swo 95% -0.6662 6.5 4.0 0.0434 -0.7466
A4DAB014_8gx9_H_F 8gx9 100% -0.7046 6.5 4.0 -0.1026 -0.7745
A4DAB014_7cdi_H_L 7cdi 100% -0.703 6.5 4.0 -0.0662 -0.7769
A4DAB014_7xnf_H_L 7xnf 100% -0.6964 6.5 4.0 0.0013 -0.7766