Elipovimab / 4fq1

A4DAB100_4fq1_H_L | Source PDB: 4fq1 | Chains: H, L | Done
96.61
Yes
10 Å
Yes
Avg A4D Score
-0.6293
Max Score
3.1566
Min Score
-3.3528
Total Score
-274.37
Score CDR
-0.1961
Score non-CDR
-0.7011

Calculation Parameters

Chain Sequence(s) QMQLQESGPGLVKPSETLSLTCSVSGASISDSYWSWIRRSPGKGLEWIGYVHKSGDTNYSPSLKSRVNLSLDTSKNQVSLSLVAATAADSGKYYCARTLHGRRIYGIVAFNEWFTYFYMDVWGNGTQVTVSSASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSSDISVAPGETARISCGEKSLGSRAVQWYQHRAGQAPSLIIYNNQDRPSGIPERFSGSPDSPFGTTATLTITSVEAGDEADYYCHIWDSRVPTKWVFGGGTTLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAP input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3528
Maximum Score 3.1566
Average Score -0.6293
Total Score -274.3697

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.5680 Soluble
2 M H -1.2176 Soluble
3 Q H -1.9912 Soluble
4 L H 0.0000 Buried
5 Q H -1.8928 Soluble
6 E H 0.0000 Buried
7 S H -0.8592 Soluble
8 G H -0.6426 Soluble
9 P H -0.7114 Soluble
11 G H 0.0000 Buried
12 L H -0.4197 Soluble
13 V H 0.0000 Buried
14 K H -1.9992 Soluble
15 P H -1.2940 Soluble
16 S H -1.2630 Soluble
17 E H -2.1121 Soluble
18 T H -0.8572 Soluble
19 L H 0.0000 Buried
20 S H -0.5412 Soluble
21 L H 0.0000 Buried
22 T H -0.4928 Soluble
23 C H 0.0000 Buried
24 S H -1.2724 Soluble
25 V H 0.0000 Buried
26 S H -1.2341 Soluble
27 G H -1.1500 Soluble
28 A H -1.0636 Soluble
29 S H -0.9308 Soluble
30 I H 0.0000 Buried
35 S H -1.5660 Soluble
36 D H -2.1030 Soluble
37 S H 0.0000 Buried
38 Y H -0.9223 Soluble
39 W H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 I H 0.0000 Buried
43 R H -0.6998 Soluble
44 R H -1.2561 Soluble
45 S H -1.1605 Soluble
46 P H -1.0795 Soluble
47 G H -1.2267 Soluble
48 K H -1.6046 Soluble
49 G H -0.9087 Soluble
50 L H 0.0000 Buried
51 E H -0.0807 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 Y H 0.0000 Buried
56 V H 0.0000 Buried
57 H H -1.8116 Soluble
58 K H -2.4941 Soluble
59 S H -1.5724 Soluble
63 G H -1.7631 Soluble
64 D H -1.8000 Soluble
65 T H -1.5513 Soluble
66 N H -1.4702 Soluble
67 Y H -0.8440 Soluble
68 S H 0.0000 Buried
69 P H -1.1525 Soluble
70 S H -0.8134 Soluble
71 L H 0.0000 Buried
72 K H -1.8867 Soluble
74 S H -1.2516 Soluble
75 R H -0.8109 Soluble
76 V H 0.0000 Buried
77 N H -1.3936 Soluble
78 L H 0.0000 Buried
79 S H -0.8587 Soluble
80 L H -0.8963 Soluble
81 D H -1.4448 Soluble
82 T H -1.3314 Soluble
83 S H -1.3303 Soluble
84 K H -2.1906 Soluble
85 N H -1.5373 Soluble
86 Q H -1.4062 Soluble
87 V H 0.0000 Buried
88 S H -0.5471 Soluble
89 L H 0.0000 Buried
90 S H -0.3958 Soluble
91 L H 0.0000 Buried
92 V H 0.0931 Aggregation-prone
93 A H -0.4476 Soluble
94 A H 0.0000 Buried
95 T H -0.3898 Soluble
96 A H -0.1057 Soluble
97 A H 0.0627 Aggregation-prone
98 D H 0.0000 Buried
99 S H -0.3313 Soluble
100 G H -0.8621 Soluble
101 K H -1.4566 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H -0.4311 Soluble
107 T H 0.0000 Buried
108 L H -0.3676 Soluble
109 H H -1.0605 Soluble
110 G H -1.0368 Soluble
111 R H -1.2608 Soluble
111A R H -0.1954 Soluble
111B I H 1.5423 Aggregation-prone
111C Y H 1.4016 Aggregation-prone
111D G H 1.7950 Aggregation-prone
111E I H 3.1566 Aggregation-prone
111F V H 2.7710 Aggregation-prone
112G A H 1.7407 Aggregation-prone
112F F H 2.2379 Aggregation-prone
112E N H 0.6822 Aggregation-prone
112D E H 1.0465 Aggregation-prone
112C W H 0.9796 Aggregation-prone
112B F H 0.0505 Aggregation-prone
112A T H -0.5405 Soluble
112 Y H 0.0000 Buried
113 F H 0.0000 Buried
114 Y H -0.0787 Soluble
115 M H 0.0000 Buried
116 D H -0.2669 Soluble
117 V H -0.1827 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 N H -1.9634 Soluble
121 G H -1.3597 Soluble
122 T H -1.1158 Soluble
123 Q H -1.0420 Soluble
124 V H 0.0000 Buried
125 T H -0.3336 Soluble
126 V H -0.4974 Soluble
127 S H -0.5424 Soluble
128 S H -0.7171 Soluble
129 A H -0.5118 Soluble
130 S H -0.6822 Soluble
131 T H -1.0197 Soluble
132 K H -1.5423 Soluble
133 G H -1.6245 Soluble
134 P H 0.0000 Buried
135 S H -0.4386 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.0543 Soluble
139 L H 0.0000 Buried
140 A H -1.3107 Soluble
141 P H 0.0000 Buried
142 S H -0.7398 Soluble
143 G H -0.7635 Soluble
144 G H -0.8607 Soluble
145 T H -0.6406 Soluble
146 A H 0.0000 Buried
147 A H -0.1016 Soluble
148 L H 0.0000 Buried
149 G H 0.0000 Buried
150 C H 0.0000 Buried
151 L H 0.0000 Buried
152 V H 0.0000 Buried
153 K H -0.5570 Soluble
154 D H -0.7186 Soluble
155 Y H 0.0000 Buried
156 F H -0.2778 Soluble
157 P H 0.0000 Buried
158 E H -0.3483 Soluble
159 P H -0.5430 Soluble
160 V H -0.4943 Soluble
161 T H -0.4316 Soluble
162 V H -0.1401 Soluble
163 S H -0.3921 Soluble
164 W H 0.0000 Buried
165 N H -0.8493 Soluble
166 S H -0.6948 Soluble
167 G H -0.5624 Soluble
168 A H -0.2577 Soluble
169 L H -0.0484 Soluble
170 T H -0.2522 Soluble
171 S H -0.2889 Soluble
172 G H -0.3733 Soluble
173 V H -0.0676 Soluble
174 H H -0.4259 Soluble
175 T H -0.1917 Soluble
176 F H 0.0000 Buried
177 P H -0.0227 Soluble
178 A H 0.3125 Aggregation-prone
179 V H 0.0000 Buried
180 L H 1.2760 Aggregation-prone
181 Q H 0.3166 Aggregation-prone
182 S H -0.1141 Soluble
183 S H -0.2195 Soluble
184 G H 0.0211 Aggregation-prone
185 L H 0.0464 Aggregation-prone
186 Y H 0.2623 Aggregation-prone
187 S H 0.0000 Buried
188 L H 0.0000 Buried
189 S H 0.0000 Buried
190 S H 0.0000 Buried
191 V H 0.0000 Buried
192 V H 0.0000 Buried
193 T H -0.2670 Soluble
194 V H 0.0000 Buried
195 P H -0.5383 Soluble
196 S H -0.5793 Soluble
197 S H -0.5951 Soluble
198 S H 0.0000 Buried
199 L H -0.8313 Soluble
200 G H -1.0453 Soluble
201 T H -0.8130 Soluble
202 Q H -1.4790 Soluble
203 T H -1.2912 Soluble
204 Y H 0.0000 Buried
205 I H -1.3027 Soluble
206 C H 0.0000 Buried
207 N H -1.3930 Soluble
208 V H 0.0000 Buried
209 N H -1.6773 Soluble
210 H H 0.0000 Buried
211 K H -2.6993 Soluble
212 P H -1.5508 Soluble
213 S H -1.8611 Soluble
214 N H -2.5752 Soluble
215 T H -2.0818 Soluble
216 K H -2.5598 Soluble
217 V H -1.5927 Soluble
218 D H -2.4671 Soluble
219 K H -2.0089 Soluble
220 R H -2.6512 Soluble
221 V H 0.0000 Buried
222 E H -2.8802 Soluble
223 P H -1.9378 Soluble
224 K H -2.3596 Soluble
225 S H -1.0875 Soluble
9 S L -1.0754 Soluble
10 D L -1.7958 Soluble
11 I L -0.6828 Soluble
12 S L -0.0577 Soluble
13 V L -0.4779 Soluble
14 A L -0.6906 Soluble
15 P L -1.4510 Soluble
16 G L -1.8858 Soluble
17 E L -2.2581 Soluble
18 T L -1.7145 Soluble
19 A L 0.0000 Buried
20 R L -1.8384 Soluble
21 I L 0.0000 Buried
22 S L -1.2343 Soluble
23 C L 0.0000 Buried
24 G L -1.6884 Soluble
25 E L -2.4775 Soluble
26 K L -2.1043 Soluble
27 S L 0.0000 Buried
28 L L 0.3566 Aggregation-prone
29 G L 0.0000 Buried
36 S L 0.0000 Buried
37 R L 0.0000 Buried
38 A L 0.0000 Buried
39 V L 0.0000 Buried
40 Q L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 H L 0.0000 Buried
45 R L -1.3111 Soluble
46 A L -1.2102 Soluble
47 G L -1.4193 Soluble
48 Q L -1.3427 Soluble
49 A L -0.9181 Soluble
50 P L 0.0000 Buried
51 S L -0.3444 Soluble
52 L L 0.0000 Buried
53 I L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.5939 Soluble
56 N L -1.0382 Soluble
57 N L 0.0000 Buried
65 Q L -1.2656 Soluble
66 D L -1.5065 Soluble
67 R L -1.7472 Soluble
68 P L -0.8593 Soluble
69 S L -0.6789 Soluble
70 G L -0.7700 Soluble
71 I L -0.7589 Soluble
72 P L -1.2199 Soluble
74 E L -2.1659 Soluble
75 R L -1.3018 Soluble
76 F L 0.0000 Buried
77 S L -1.1607 Soluble
78 G L 0.0000 Buried
79 S L -0.5532 Soluble
80 P L -0.4492 Soluble
81 D L -0.0838 Soluble
82 S L -0.0103 Soluble
82A P L 0.3948 Aggregation-prone
83 F L 1.2725 Aggregation-prone
84 G L -0.0668 Soluble
85 T L -0.5552 Soluble
86 T L -1.1317 Soluble
87 A L 0.0000 Buried
88 T L -0.7208 Soluble
89 L L 0.0000 Buried
90 T L -0.8834 Soluble
91 I L 0.0000 Buried
92 T L -1.6149 Soluble
93 S L -1.5626 Soluble
94 V L 0.0000 Buried
95 E L -2.2528 Soluble
96 A L -1.2308 Soluble
97 G L -1.2274 Soluble
98 D L 0.0000 Buried
99 E L 0.0000 Buried
100 A L 0.0000 Buried
101 D L -0.8688 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 H L 0.0000 Buried
106 I L 0.0000 Buried
107 W L 0.0000 Buried
108 D L 0.0000 Buried
109 S L -0.4480 Soluble
110 R L -1.3319 Soluble
112 V L -0.3424 Soluble
113 P L -0.6088 Soluble
114 T L -0.6023 Soluble
115 K L -0.7615 Soluble
116 W L 0.0000 Buried
117 V L 0.6272 Aggregation-prone
118 F L 0.0000 Buried
119 G L -0.5322 Soluble
120 G L -0.9140 Soluble
121 G L 0.0000 Buried
122 T L -1.0384 Soluble
123 T L -0.9545 Soluble
124 L L 0.0000 Buried
125 T L -0.3143 Soluble
126 V L 0.0000 Buried
127 L L 0.4336 Aggregation-prone
128 G L -0.4162 Soluble
129 Q L -0.9252 Soluble
130 P L -1.1454 Soluble
131 K L -2.2170 Soluble
132 A L -1.2205 Soluble
133 A L -0.7742 Soluble
134 P L -0.4802 Soluble
135 S L -0.1767 Soluble
136 V L -0.3268 Soluble
137 T L -0.2674 Soluble
138 L L -0.2556 Soluble
139 F L 0.0000 Buried
140 P L -0.0796 Soluble
141 P L 0.0000 Buried
142 S L -1.1190 Soluble
143 S L -1.6703 Soluble
144 E L -2.4057 Soluble
145 E L 0.0000 Buried
146 L L -1.9987 Soluble
147 Q L -2.4081 Soluble
148 A L -1.9752 Soluble
149 N L -2.8084 Soluble
150 K L -2.9084 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L 0.0000 Buried
159 D L -0.7373 Soluble
160 F L 0.0000 Buried
161 Y L -0.9840 Soluble
162 P L -0.9352 Soluble
163 G L -0.5345 Soluble
164 A L -0.1783 Soluble
165 V L -0.0669 Soluble
166 T L -0.0624 Soluble
167 V L 0.0713 Aggregation-prone
168 A L -0.5035 Soluble
169 W L 0.0000 Buried
170 K L -1.0063 Soluble
171 A L 0.0000 Buried
172 D L -1.2539 Soluble
173 S L -0.8374 Soluble
174 S L -0.7250 Soluble
175 P L -0.7739 Soluble
176 V L -0.8154 Soluble
177 K L -1.6772 Soluble
178 A L -0.8869 Soluble
179 G L -0.7609 Soluble
180 V L -0.5445 Soluble
181 E L -0.3665 Soluble
182 T L 0.0627 Aggregation-prone
183 T L 0.0953 Aggregation-prone
184 T L 0.0214 Aggregation-prone
185 P L -0.2304 Soluble
186 S L -0.4765 Soluble
187 K L -1.0036 Soluble
188 Q L -1.3170 Soluble
189 S L -1.4779 Soluble
190 N L -1.7990 Soluble
191 N L 0.0000 Buried
192 K L -1.2362 Soluble
193 Y L -0.5149 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.7357 Soluble
201 L L 0.0000 Buried
202 T L -2.0728 Soluble
203 P L -2.6145 Soluble
204 E L -3.3528 Soluble
205 Q L -2.6991 Soluble
206 W L 0.0000 Buried
207 K L -3.3378 Soluble
208 S L -2.6589 Soluble
209 H L -2.5633 Soluble
210 R L -2.6061 Soluble
211 S L -1.5530 Soluble
212 Y L 0.0000 Buried
213 S L 0.0000 Buried
214 C L 0.0000 Buried
215 Q L -0.9887 Soluble
216 V L 0.0000 Buried
217 T L -0.7091 Soluble
218 H L 0.0000 Buried
219 E L -2.3274 Soluble
220 G L -1.4510 Soluble
221 S L -1.1436 Soluble
222 T L -0.8199 Soluble
223 V L -0.8028 Soluble
224 E L -2.0903 Soluble
225 K L -1.5097 Soluble
226 T L -0.8570 Soluble
227 V L -0.2969 Soluble
228 A L -0.8476 Soluble
229 P L -1.1252 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.575 5.4304 CSV PDB
4.5 -0.6096 5.3992 CSV PDB
5.0 -0.6505 5.3543 CSV PDB
5.5 -0.6886 5.3033 CSV PDB
6.0 -0.7128 5.2542 CSV PDB
6.5 -0.7152 5.2148 CSV PDB
7.0 -0.6967 5.1909 CSV PDB
7.5 -0.6642 5.1802 CSV PDB
8.0 -0.6234 5.1763 CSV PDB
8.5 -0.5769 5.1749 CSV PDB
9.0 -0.5263 5.1745 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH