Caplacizumab

A4DAB061 | Cardiovascular / hemostasis disorders | Approved
VWF
non-canonical / None
Ablynx
Approved
Whole mAb
ALX-0081 ALX0081 ALX-0681 ALX0681
6.5
IMGT PubChem (160671749) PubChem (315661208) PubChem (381125787) PubChem (404770101) PubChem (472423118) PubChem (472435550) PubChem (472440357) PubChem (481155461) PubChem (483929155) PubChem (498124476) PubChem (517689394) PubChem (517704479) Thera-SAbDab YAbS
Avg A4D Score
-0.6045
Score Range
-0.65 to -0.56
Structures
4
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB061_7wvm_C_D 7wvm 100% -0.5573 8.0 4.0 -0.5954 -0.548
A4DAB061_7wvm_A_B 7wvm 100% -0.5631 8.0 4.0 -0.5232 -0.5729
A4DAB061_8gy5_H_L 8gy5 100% -0.645 6.5 4.0 -0.5211 -0.6594
A4DAB061_8gy5_A_B 8gy5 100% -0.6524 6.5 4.0 -0.5635 -0.6627