Dupilumab

A4DAB093 | Immune-mediated / inflammatory disorders | Approved
IL4R/CD124
G4 / IgG4
Aimmune Therapeutics Regeneron Pharmaceuticals Sanofi
Approved
Whole mAb
Dupixent REGN-668 REGN668 SAR-231893 SAR231893
5.9
Avg A4D Score
-0.6944
Score Range
-0.76 to -0.66
Structures
11
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB093_6wgj_A_B 6wgj 100% -0.6976 6.5 4.0 -0.3159 -0.7545
A4DAB093_6wgj_E_F 6wgj 100% -0.6765 6.5 4.0 -0.1162 -0.7635
A4DAB093_6wgk_A_B 6wgk 100% -0.6595 6.5 4.0 -0.1365 -0.7388
A4DAB093_6wgk_C_D 6wgk 100% -0.6756 7.0 4.0 -0.1163 -0.7608
A4DAB093_6wgl_A_B 6wgl 100% -0.6861 6.5 4.0 -0.1186 -0.771
A4DAB093_6wgk_G_H 6wgk 100% -0.6669 6.5 4.0 -0.2542 -0.7854
A4DAB093_6wgb_C_D 6wgb 100% -0.7626 6.5 4.0 N/A N/A
A4DAB093_6wgj_C_D 6wgj 100% -0.7383 7.0 4.0 -0.2847 -0.8062
A4DAB093_6wg8_A_B 6wg8 100% -0.6585 6.5 4.0 -0.1035 -0.7424
A4DAB093_6wgk_E_F 6wgk 100% -0.6757 6.5 4.0 -0.0915 -0.7642
A4DAB093_6wgb_A_B 6wgb 100% -0.7416 6.5 4.0 -0.493 -0.8069