Glofitamab

A4DAB132 | Cancer | Approved
CD3E;MS4A1/CD20
G1;G1 / IgG1
Roche
Approved
Bispecific mAb with Domain Crossover
Columvi RG 6026 RG6026 RG-6026 RO 7082859 RO-7082859 RO7082859
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IMGT PubChem (402425894) PubChem (404720264) PubChem (464013591) PubChem (468575052) PubChem (472419993) PubChem (481155467) PubChem (483123306) PubChem (483927794) PubChem (498145174) PubChem (505188564) Thera-SAbDab YAbS
Avg A4D Score
-0.6894
Score Range
-0.72 to -0.62
Structures
4
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB132_6y97_H_L 6y97 100% -0.62 7.0 4.0 N/A N/A
A4DAB132_3pp4_H_L 3pp4 100% -0.7056 6.5 9.0 N/A N/A
A4DAB132_3pp3_H_L 3pp3 100% -0.7144 6.5 9.0 N/A N/A
A4DAB132_6y9a_H_L 6y9a 100% -0.7177 6.5 4.0 N/A N/A