Olokizumab

A4DAB190 | Immune-mediated / inflammatory disorders | Approved

Target IL6

Isotype / Subclass G4 / IgG4

Company

R-Pharm UCB

Clinical Status Approved

Format Whole mAb

Synonyms

Artlegia CDP-6038 CDP6038 CDP 6038

pH Formulation —

IMGT PubChem (160677293) PubChem (347911425) PubChem (381126049) PubChem (442878635) PubChem (472408106) PubChem (472435536) PubChem (472440386) PubChem (481155483) PubChem (498156024) PubChem (505852682) Thera-SAbDab YAbS

Avg A4D Score

-0.7488

Score Range

-0.76 to -0.73

Structures

2

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Structure ID	Source PDB	Seq. Identity	Avg. A4D Score	pH (Min Agg.)	pH (Max Agg.)	Score CDR	Score non-CDR
A4DAB190_4cni_H_L	4cni	100%	-0.734	6.5	4.0	-0.4436	-0.7693
A4DAB190_4cni_A_B	4cni	100%	-0.7635	6.5	4.0	-0.5891	-0.7847

Olokizumab

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2