Tiragolumab

A4DAB268 | Cancer | Phase-III
TIGIT/WUCAM/VSTM3
G1 / IgG1
Genentech
Phase-III
Whole mAb
MTIG-7192A MTIG7192A MTIG 7192A RG-6058 RG6058 RG 6058 RO 7092284 RO-7092284 RO7092284
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IMGT PubChem (381128164) PubChem (404719438) PubChem (472419169) PubChem (481155456) PubChem (498149479) PubChem (505056138) PubChem (505894150) PubChem (517704472) Thera-SAbDab YAbS
Avg A4D Score
-0.6614
Score Range
-0.68 to -0.64
Structures
3
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB268_8jeq_A_B 8jeq 100% -0.6688 6.0 9.0 -0.2022 -0.7386
A4DAB268_8jeo_E_F 8jeo 100% -0.6405 6.5 4.0 -0.045 -0.7332
A4DAB268_8jeo_B_C 8jeo 100% -0.675 6.5 4.0 -0.1193 -0.76