Aggrescan3D

A server for prediction of aggregation propensity in protein structures and rational design of protein solubility. In dynamic mode, A3D takes into account the flexibility of natural and designed polypeptides.

Papers describing Aggrescan3D development and applications:

4. Aggrescan3D (A3D) 2.0: prediction and engineering of protein solubility

Nucleic Acids Research, 47: W300-W307, 2019
Kuriata Aleksander, Iglesias Valentin, Pujols Jordi, Kurciński Mateusz , Kmiecik Sebastian, Ventura Salvador

3. Aggrescan3D standalone package for structure-based prediction of protein aggregation properties

Bioinformatics, btz143, 2019
Kuriata Aleksander, Iglesias V., Kurciński Mateusz , Ventura S., Kmiecik Sebastian

2. Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility

Molecular Pharmaceutics, 15: 3846-3859, 2018
Gil-Garcia Marcos, Bano-Polo Manuel, Varejao Nathalia, Jarnroz Michal, Kuriata Aleksander, Diaz-Caballero Marta, Lascorz Jara, More Bertrand, Navarro Susanna, Reverter David, Kmiecik Sebastian, Ventura Salvador

1. AGGRESCAN3D (A3D): server for prediction of aggregation properties of protein structures

Nucleic Acids Research, 43: W306-W313, 2015
Zambrano Rafael, Jamroz Michal, Szczasiuk Agata, Pujols Jordi, Kmiecik Sebastian, Ventura Salvador

Who we are?

We are group of life science researchers with different backgrounds: chemistry, bioinformatics, physics and medical sciences. We mainly work on development and applications of molecular modeling tools in biology and medicine. Our interests embrace broad aspects of computational biology, from molecular simulations to data analysis.

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