Cetuximab

A4DAB063 | Cancer | Approved
EGFR/ERBB1/HER1
G1 / IgG1
Array BioPharma Bristol-Myers Squibb Celldex Therapeutics Inc Centre Jean Perrin Eli Lilly Merck KGaA New York University School of Medicine Novartis Pierre Fabre Roche University Hospital Ghent University of California University of Heidelberg University of Michigan Comprehensive Cancer Center
Approved
Whole mAb
IMC-C225 IMC C225 LY-2939777 LY2939777
7.0-7.4
IMGT PubChem (495888) PubChem (532611) PubChem (46507042) PubChem (103771411) PubChem (135293496) PubChem (178103464) PubChem (329976961) PubChem (348480208) PubChem (348892040) PubChem (350080042) PubChem (354355046) PubChem (387061106) PubChem (440790714) PubChem (441072527) PubChem (445933985) PubChem (446094829) PubChem (468762434) PubChem (469690936) PubChem (472186809) PubChem (472386399) PubChem (472677711) PubChem (475546936) PubChem (481101564) PubChem (481155116) PubChem (485441611) PubChem (488235390) PubChem (496156059) PubChem (497705298) PubChem (498148318) PubChem (500132709) PubChem (507648546) PubChem (508644796) PubChem (513261102) PubChem (519964949) Thera-SAbDab YAbS
Avg A4D Score
-0.6741
Score Range
-0.73 to -0.63
Structures
70
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB063_5iop_B_A 5iop 100% -0.7003 6.5 4.0 -0.3463 -0.7429
A4DAB063_5t1k_D_C 5t1k 100% -0.6788 6.5 4.0 -0.307 -0.7236
A4DAB063_5itf_D_C 5itf 100% -0.6702 6.5 9.0 -0.3005 -0.7148
A4DAB063_6au5_B_A 6au5 100% -0.6773 6.5 9.0 -0.2764 -0.7251
A4DAB063_5gz0_D_C 5gz0 98% -0.7156 6.5 9.0 -0.2865 -0.7665
A4DAB063_5t1m_D_C 5t1m 100% -0.6312 6.5 4.0 -0.3064 -0.6705
A4DAB063_5etu_B_A 5etu 100% -0.697 6.5 4.0 -0.2859 -0.7465
A4DAB063_5icy_D_C 5icy 100% -0.6487 6.5 4.0 -0.2437 -0.6981
A4DAB063_4gw5_B_A 4gw5 100% -0.7013 6.5 4.0 -0.3172 -0.7476
A4DAB063_1yy8_B_A 1yy8 100% -0.695 6.5 9.0 -0.3386 -0.7372
A4DAB063_4gw5_D_C 4gw5 100% -0.6943 6.5 4.0 -0.2934 -0.7425
A4DAB063_5ir1_B_A 5ir1 100% -0.6668 6.5 9.0 -0.2913 -0.7117
A4DAB063_5esq_B_A 5esq 100% -0.7025 6.5 4.0 -0.3079 -0.7501
A4DAB063_5t1m_B_A 5t1m 100% -0.6608 6.5 9.0 -0.2305 -0.7125
A4DAB063_5i2i_B_A 5i2i 100% -0.6537 6.5 4.0 -0.318 -0.6936
A4DAB063_5ff6_D_C 5ff6 100% -0.6898 6.5 4.0 -0.2901 -0.7385
A4DAB063_5itf_B_A 5itf 100% -0.6619 6.5 9.0 -0.3013 -0.7052
A4DAB063_6azl_B_A 6azl 100% -0.6865 6.5 4.0 -0.3296 -0.7291
A4DAB063_5hyq_B_A 5hyq 100% -0.6874 6.5 4.0 -0.3281 -0.7301
A4DAB063_6azl_D_C 6azl 100% -0.6605 6.5 9.0 -0.292 -0.705
A4DAB063_6ayn_B_A 6ayn 100% -0.6534 6.5 9.0 -0.2645 -0.6999
A4DAB063_5gz0_B_A 5gz0 98% -0.709 6.5 4.0 -0.3431 -0.7524
A4DAB063_6axp_D_C 6axp 100% -0.6587 6.5 9.0 -0.3064 -0.7014
A4DAB063_1yy8_D_C 1yy8 100% -0.688 6.5 4.0 -0.3512 -0.728
A4DAB063_5hpm_B_A 5hpm 100% -0.6612 6.5 4.0 -0.3495 -0.6987
A4DAB063_5euk_D_C 5euk 100% -0.6737 6.5 4.0 -0.3334 -0.7149
A4DAB063_4kro_D_C 4kro 100% -0.6714 6.5 9.0 -0.3007 -0.7165
A4DAB063_6arp_B_A 6arp 98% -0.7263 6.5 4.0 -0.5068 -0.7528
A4DAB063_5f88_D_C 5f88 100% -0.6308 6.5 4.0 -0.2619 -0.6755
A4DAB063_5hpm_D_C 5hpm 100% -0.6627 6.5 4.0 -0.3267 -0.7032
A4DAB063_6au5_D_C 6au5 100% -0.6601 6.5 9.0 -0.3185 -0.7007
A4DAB063_6ayn_D_C 6ayn 100% -0.6517 6.5 9.0 -0.3128 -0.6923
A4DAB063_5id1_D_C 5id1 100% -0.6734 6.5 9.0 -0.2951 -0.7194
A4DAB063_5hyq_D_C 5hyq 100% -0.6529 6.5 4.0 -0.3068 -0.6948
A4DAB063_5t1k_B_A 5t1k 100% -0.6473 6.5 4.0 -0.2839 -0.6909
A4DAB063_5ivz_B_A 5ivz 100% -0.6634 6.5 4.0 -0.2878 -0.7075
A4DAB063_5icz_B_A 5icz 100% -0.6782 6.5 9.0 -0.2618 -0.7284
A4DAB063_5id0_B_A 5id0 100% -0.6784 6.5 4.0 -0.2643 -0.7279
A4DAB063_5icx_D_C 5icx 100% -0.651 6.5 9.0 -0.2981 -0.694
A4DAB063_5esq_D_C 5esq 100% -0.6861 6.5 9.0 -0.3049 -0.7328
A4DAB063_4gw1_D_C 4gw1 100% -0.6514 6.5 4.0 -0.2854 -0.6949
A4DAB063_5i76_D_C 5i76 100% -0.6813 6.5 4.0 -0.3195 -0.7246
A4DAB063_6azk_D_C 6azk 100% -0.6388 6.5 4.0 -0.2932 -0.68
A4DAB063_5i2i_D_C 5i2i 100% -0.6472 6.5 4.0 -0.278 -0.6916
A4DAB063_5icy_B_A 5icy 100% -0.6473 6.5 9.0 -0.2606 -0.6937
A4DAB063_5id1_B_A 5id1 100% -0.6811 6.5 9.0 -0.2847 -0.7291
A4DAB063_6aru_C_B 6aru 98% -0.7008 6.5 4.0 -0.4134 -0.736
A4DAB063_5euk_B_A 5euk 100% -0.6769 6.5 4.0 -0.3391 -0.7173
A4DAB063_5ir1_D_C 5ir1 100% -0.6855 6.5 9.0 -0.3556 -0.7249
A4DAB063_5ff6_B_A 5ff6 100% -0.6653 6.5 9.0 -0.3027 -0.7085
A4DAB063_5icz_D_C 5icz 100% -0.6811 6.5 4.0 -0.2896 -0.7285
A4DAB063_4krp_D_C 4krp 100% -0.6736 6.5 9.0 -0.3074 -0.7182
A4DAB063_6arp_D_C 6arp 98% -0.7346 7.0 4.0 -0.5131 -0.7611
A4DAB063_1yy9_D_C 1yy9 100% -0.6862 6.5 9.0 -0.3108 -0.731
A4DAB063_5i76_B_A 5i76 100% -0.6906 6.5 4.0 -0.3198 -0.7346
A4DAB063_5iv2_B_A 5iv2 100% -0.6822 6.5 4.0 -0.2951 -0.7288
A4DAB063_5t1l_B_A 5t1l 100% -0.6613 6.5 4.0 -0.2564 -0.7092
A4DAB063_5f88_B_A 5f88 100% -0.6671 6.5 4.0 -0.3081 -0.7103
A4DAB063_6azk_B_A 6azk 100% -0.6752 6.5 4.0 -0.3353 -0.7161
A4DAB063_4gw1_B_A 4gw1 100% -0.6843 6.5 9.0 -0.3432 -0.7248
A4DAB063_5id0_D_C 5id0 100% -0.657 6.5 4.0 -0.247 -0.7071
A4DAB063_5ivz_D_C 5ivz 100% -0.6465 6.5 4.0 -0.2826 -0.6909
A4DAB063_5iv2_D_C 5iv2 100% -0.6696 6.5 4.0 -0.2951 -0.7152
A4DAB063_5t1l_D_C 5t1l 100% -0.66 6.5 9.0 -0.295 -0.7043
A4DAB063_5th2_D_C 5th2 100% -0.6745 6.5 9.0 -0.2746 -0.7229
A4DAB063_6axp_B_A 6axp 100% -0.6984 6.5 9.0 -0.3579 -0.739
A4DAB063_5iop_D_C 5iop 100% -0.6936 6.5 4.0 -0.321 -0.7387
A4DAB063_5icx_B_A 5icx 100% -0.6934 6.5 4.0 -0.3081 -0.7394
A4DAB063_5etu_D_C 5etu 100% -0.664 6.5 4.0 -0.2925 -0.7092
A4DAB063_5th2_B_A 5th2 100% -0.6594 6.5 4.0 -0.2861 -0.7047