Crenezumab

A4DAB074 | Phase-II
APP
G4 / None
AC Immune Genentech Universidad de Antioquia
Phase-II
Whole mAb
MABT5102A MABT-5102A R 5490245 R5490245 R-5490245 RG 7412 RG7412 RG-7412 RO 5490245 RO5490245 RO-5490245
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IMGT PubChem (160693412) PubChem (178103516) PubChem (347911262) PubChem (381126310) PubChem (472397307) PubChem (480403235) PubChem (481988098) PubChem (505575133) PubChem (513904335) PubChem (519918852) Thera-SAbDab YAbS
Avg A4D Score
-0.7317
Score Range
-0.76 to -0.69
Structures
3
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB074_5vzy_H_L 5vzy 100% -0.6949 6.5 4.0 -0.3004 -0.7406
A4DAB074_5vzx_H_L 5vzx 100% -0.7604 6.5 4.0 -0.4166 -0.7994
A4DAB074_5vzx_E_I 5vzx 100% -0.7397 6.5 4.0 -0.3817 -0.7802