Infliximab

A4DAB142 | Immune-mediated / inflammatory disorders | Approved
TNF/TNFA
G1 / IgG1
Centocor Janssen Biotech Merck & Co Mitsubishi Tanabe Pharma Corporation National Jewish Medical and Research Center Xian-Janssen
Approved
Whole mAb
cA2 CenTNF Remicade TA-650 TA650 TA 650
7.2
IMGT PubChem (46505602) PubChem (50067186) PubChem (91145133) PubChem (103771449) PubChem (135305802) PubChem (178101701) PubChem (329976987) PubChem (348825932) PubChem (354355050) PubChem (387060165) PubChem (433790701) PubChem (433791528) PubChem (440790341) PubChem (441072528) PubChem (468742313) PubChem (469690933) PubChem (472186725) PubChem (472423472) PubChem (475546921) PubChem (481101685) PubChem (481155370) PubChem (485726170) PubChem (486300343) PubChem (488211629) PubChem (496156064) PubChem (498150919) PubChem (508644815) PubChem (513259867) PubChem (519875136) Thera-SAbDab YAbS
Avg A4D Score
-0.6929
Score Range
-0.71 to -0.67
Structures
13
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB142_6ugs_H_L 6ugs 100% -0.6988 6.5 4.0 -0.1541 -0.7654
A4DAB142_5vh4_A_B 5vh4 100% -0.6904 6.5 4.0 -0.1394 -0.7575
A4DAB142_4g3y_H_L 4g3y 100% -0.6951 6.5 4.0 -0.1969 -0.7556
A4DAB142_6ugt_H_L 6ugt 100% -0.691 6.5 4.0 -0.1848 -0.7526
A4DAB142_5vh3_A_B 5vh3 100% -0.6755 6.5 4.0 -0.1556 -0.7389
A4DAB142_6ugv_A_B 6ugv 100% -0.6947 6.5 4.0 -0.1742 -0.758
A4DAB142_6ugu_A_B 6ugu 100% -0.67 6.5 4.0 -0.097 -0.7399
A4DAB142_6ugu_H_L 6ugu 100% -0.6949 6.5 9.0 -0.1354 -0.7635
A4DAB142_5vh3_H_L 5vh3 100% -0.6963 6.5 4.0 -0.1515 -0.7629
A4DAB142_6ugv_H_L 6ugv 100% -0.7125 6.5 4.0 -0.1635 -0.7791
A4DAB142_6ugt_A_B 6ugt 100% -0.6979 6.5 4.0 -0.1485 -0.7648
A4DAB142_6ugs_A_B 6ugs 100% -0.7012 6.5 9.0 -0.1465 -0.7675
A4DAB142_5vh4_H_L 5vh4 100% -0.6889 6.5 4.0 -0.1659 -0.7527