Zenocutuzumab

A4DAB306 | Cancer | Approved
ERBB3/HER3;ERBB2/CD340/HER2
G1;G1 / IgG1
Merus
Approved
Bispecific mAb
MCLA-128 MCLA128 MCLA 128
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IMGT PubChem (381128193) PubChem (404720332) PubChem (404772984) PubChem (472419170) PubChem (476262837) PubChem (476269383) PubChem (505900750) PubChem (507750283) PubChem (508534392) Thera-SAbDab YAbS
Avg A4D Score
-0.659
Score Range
-0.68 to -0.62
Structures
3
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB306_5o7p_B_A 5o7p 100% -0.6778 6.5 9.0 -0.175 -0.7453
A4DAB306_5o4o_B_A 5o4o 100% -0.6755 6.5 4.0 -0.1851 -0.7417
A4DAB306_5o4g_B_A 5o4g 100% -0.6236 6.5 4.0 0.1554 -0.7215