Bimagrumab

A4DAB047 | Phase-II
ACVR2B
G1 / None
MorphoSys Novartis
Phase-II
Whole mAb
BYM-338 BYM338
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IMGT PubChem (194189084) PubChem (249565766) PubChem (347911347) PubChem (381127086) PubChem (472406523) PubChem (476262689) PubChem (476269292) PubChem (498153410) PubChem (505564077) PubChem (517689166) Thera-SAbDab YAbS
Avg A4D Score
-0.5185
Score Range
-0.62 to -0.45
Structures
6
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB047_5nhw_H_L 5nhw 100% -0.6214 6.0 9.0 0.0041 -0.6992
A4DAB047_5nhr_A_B 5nhr 100% -0.5334 6.0 9.0 -0.0586 -0.656
A4DAB047_5nh3_I_M 5nh3 100% -0.4895 6.0 9.0 0.0095 -0.622
A4DAB047_5ngv_H_L 5ngv 100% -0.5012 6.0 9.0 -0.0544 -0.6199
A4DAB047_5nh3_H_L 5nh3 100% -0.4537 6.0 9.0 -0.0005 -0.574
A4DAB047_5nhr_H_L 5nhr 100% -0.5121 6.0 9.0 -0.0408 -0.6359