Lampalizumab

A4DAB150 | Ophthalmic disorders | Phase-III
CFD
G1 / None
Tanox Genentech
Phase-III
Fab
FCFD4514S RG7417 RG-7417 RG 7417 RO 5490249 RO5490249 RO-5490249 TNX-234 TNX 234 TXN234
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IMGT PubChem (160687723) PubChem (252166506) PubChem (347911244) PubChem (381126863) PubChem (472405406) PubChem (474488734) PubChem (474489085) PubChem (505794157) PubChem (513905188) Thera-SAbDab YAbS
Avg A4D Score
-0.7005
Score Range
-0.72 to -0.68
Structures
4
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB150_4d9r_E_D 4d9r 100% -0.6927 6.5 4.0 -0.7066 -0.6912
A4DAB150_4d9r_H_L 4d9r 100% -0.6846 6.5 4.0 -0.6642 -0.6868
A4DAB150_4d9q_E_D 4d9q 100% -0.703 6.5 4.0 -0.6873 -0.7047
A4DAB150_4d9q_H_L 4d9q 100% -0.7215 6.5 4.0 -0.7017 -0.7236