Otilimab

A4DAB198 | Immune-mediated / inflammatory disorders | Phase-III
CSF2
G1 / IgG1
GlaxoSmithKline MorphoSys
Phase-III
Whole mAb
GSK-3196165 GSK3196165 GSK 3196165 GSK165 GSK-165 GSK 165 MOR-103 MOR 103 MOR103
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IMGT PubChem (160682411) PubChem (381127828) PubChem (404770186) PubChem (434122192) PubChem (472419226) PubChem (480403208) PubChem (481988071) PubChem (505852917) PubChem (513905885) Thera-SAbDab YAbS
Avg A4D Score
-0.6847
Score Range
-0.71 to -0.64
Structures
6
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB198_5d72_M_N 5d72 97% -0.6395 6.0 9.0 -0.4375 -0.6629
A4DAB198_5c7x_H_L 5c7x 100% -0.7095 6.0 9.0 -0.5761 -0.7248
A4DAB198_5d72_H_L 5d72 97% -0.7 6.0 9.0 -0.4261 -0.7313
A4DAB198_5c7x_M_N 5c7x 100% -0.6806 6.0 9.0 -0.621 -0.6875
A4DAB198_5d71_H_L 5d71 96% -0.6799 6.5 4.0 -0.3756 -0.7213
A4DAB198_5d7s_H_L 5d7s 100% -0.6985 6.0 9.0 -0.5793 -0.7119