Utomilumab

A4DAB286 | Cancer | Phase-II
TNFRSF9/CD137/4-1BB
G2 / IgG2
Dana-Farber Cancer Institute Immatics US Kite Pharma Kyowa Hakko Kirin M. D. Anderson Cancer Center Pfizer
Phase-II
Whole mAb
PF-05082566 PF05082566 PF-5082566 PF5082566 PF-2566 PF2566
—
IMGT PubChem (315661319) PubChem (318464561) PubChem (381127322) PubChem (404772553) PubChem (472407257) PubChem (488414511) PubChem (497983042) PubChem (505056126) PubChem (505897437) Thera-SAbDab YAbS
Avg A4D Score
-0.5955
Score Range
-0.68 to -0.54
Structures
6
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB286_6mi2_D_E 6mi2 100% -0.6798 6.0 9.0 -0.1389 -0.7447
A4DAB286_6a3w_G_H 6a3w 100% -0.5772 6.5 4.0 -0.1768 -0.6784
A4DAB286_6mi2_A_B 6mi2 100% -0.6658 6.0 9.0 -0.2536 -0.7155
A4DAB286_6a3w_A_B 6a3w 100% -0.5564 6.5 9.0 -0.187 -0.6509
A4DAB286_6a3w_J_K 6a3w 100% -0.551 6.5 4.0 -0.1867 -0.6436
A4DAB286_6a3w_D_E 6a3w 100% -0.5426 6.5 4.0 -0.1728 -0.6361