Amatuximab

A4DAB011 | Phase-II
MSLN
G1 / None
Eisai Co Ltd Morphotek National Cancer Institute (USA)
Phase-II
Whole mAb
MORAb-009 MORAB-009-006 MORAb009
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IMGT PubChem (135289484) PubChem (160704149) PubChem (223366083) PubChem (347911395) PubChem (464013575) PubChem (468575015) PubChem (472392929) PubChem (481155558) PubChem (498124135) PubChem (505552597) PubChem (517704471) Thera-SAbDab YAbS
Avg A4D Score
-0.6909
Score Range
-0.71 to -0.67
Structures
7
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB011_4f33_D_C 4f33 100% -0.707 6.0 9.0 -0.3819 -0.7451
A4DAB011_4f33_B_A 4f33 100% -0.6981 6.0 9.0 -0.3703 -0.7366
A4DAB011_7ued_H_L 7ued 100% -0.6686 6.0 9.0 -0.3133 -0.71
A4DAB011_4f33_H_G 4f33 100% -0.6839 6.0 9.0 -0.3384 -0.7245
A4DAB011_4f33_F_E 4f33 100% -0.676 6.0 9.0 -0.2848 -0.7219
A4DAB011_4f3f_B_A 4f3f 100% -0.7031 6.0 9.0 -0.329 -0.7469
A4DAB011_8cxc_H_L 8cxc 52% -0.6999 6.5 4.0 0.0378 -0.7885