Ficerafusp

A4DAB117 | Phase-II/III
EGFR/ERBB1/HER1
G1 / None
Bicara Therapeutics
Phase-II/III
Fusion Protein
BCA101 BCA-101
—
Avg A4D Score
-0.6741
Score Range
-0.73 to -0.63
Structures
70
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB117_5th2_D_C 5th2 100% -0.6745 6.5 9.0 -0.2746 -0.7229
A4DAB117_4gw5_B_A 4gw5 100% -0.7013 6.5 4.0 -0.3172 -0.7476
A4DAB117_5id1_B_A 5id1 100% -0.6811 6.5 9.0 -0.2847 -0.7291
A4DAB117_5icy_B_A 5icy 100% -0.6473 6.5 9.0 -0.2606 -0.6937
A4DAB117_6azk_B_A 6azk 100% -0.6752 6.5 4.0 -0.3353 -0.7161
A4DAB117_5icy_D_C 5icy 100% -0.6487 6.5 4.0 -0.2437 -0.6981
A4DAB117_5id1_D_C 5id1 100% -0.6734 6.5 9.0 -0.2951 -0.7194
A4DAB117_5id0_B_A 5id0 100% -0.6784 6.5 4.0 -0.2643 -0.7279
A4DAB117_5i2i_B_A 5i2i 100% -0.6537 6.5 4.0 -0.318 -0.6936
A4DAB117_5itf_B_A 5itf 100% -0.6619 6.5 9.0 -0.3013 -0.7052
A4DAB117_5euk_B_A 5euk 100% -0.6769 6.5 4.0 -0.3391 -0.7173
A4DAB117_6axp_D_C 6axp 100% -0.6587 6.5 9.0 -0.3064 -0.7014
A4DAB117_5f88_D_C 5f88 100% -0.6308 6.5 4.0 -0.2619 -0.6755
A4DAB117_4gw1_D_C 4gw1 100% -0.6514 6.5 4.0 -0.2854 -0.6949
A4DAB117_5t1m_B_A 5t1m 100% -0.6608 6.5 9.0 -0.2305 -0.7125
A4DAB117_5t1m_D_C 5t1m 100% -0.6312 6.5 4.0 -0.3064 -0.6705
A4DAB117_5iv2_D_C 5iv2 100% -0.6696 6.5 4.0 -0.2951 -0.7152
A4DAB117_5hyq_B_A 5hyq 100% -0.6874 6.5 4.0 -0.3281 -0.7301
A4DAB117_5esq_D_C 5esq 100% -0.6861 6.5 9.0 -0.3049 -0.7328
A4DAB117_5etu_D_C 5etu 100% -0.664 6.5 4.0 -0.2925 -0.7092
A4DAB117_5ivz_D_C 5ivz 100% -0.6465 6.5 4.0 -0.2826 -0.6909
A4DAB117_4gw5_D_C 4gw5 100% -0.6943 6.5 4.0 -0.2934 -0.7425
A4DAB117_5gz0_D_C 5gz0 98% -0.7156 6.5 9.0 -0.2865 -0.7665
A4DAB117_5iop_D_C 5iop 100% -0.6936 6.5 4.0 -0.321 -0.7387
A4DAB117_5hpm_D_C 5hpm 100% -0.6627 6.5 4.0 -0.3267 -0.7032
A4DAB117_5t1l_D_C 5t1l 100% -0.66 6.5 9.0 -0.295 -0.7043
A4DAB117_5hpm_B_A 5hpm 100% -0.6612 6.5 4.0 -0.3495 -0.6987
A4DAB117_1yy8_B_A 1yy8 100% -0.695 6.5 9.0 -0.3386 -0.7372
A4DAB117_5icz_D_C 5icz 100% -0.6811 6.5 4.0 -0.2896 -0.7285
A4DAB117_5i76_B_A 5i76 100% -0.6906 6.5 4.0 -0.3198 -0.7346
A4DAB117_6aru_C_B 6aru 98% -0.7008 6.5 4.0 -0.4134 -0.736
A4DAB117_6azl_B_A 6azl 100% -0.6865 6.5 4.0 -0.3296 -0.7291
A4DAB117_4krp_D_C 4krp 100% -0.6736 6.5 9.0 -0.3074 -0.7182
A4DAB117_5i76_D_C 5i76 100% -0.6813 6.5 4.0 -0.3195 -0.7246
A4DAB117_5etu_B_A 5etu 100% -0.697 6.5 4.0 -0.2859 -0.7465
A4DAB117_5itf_D_C 5itf 100% -0.6702 6.5 9.0 -0.3005 -0.7148
A4DAB117_4kro_D_C 4kro 100% -0.6714 6.5 9.0 -0.3007 -0.7165
A4DAB117_5iv2_B_A 5iv2 100% -0.6822 6.5 4.0 -0.2951 -0.7288
A4DAB117_5t1k_D_C 5t1k 100% -0.6788 6.5 4.0 -0.307 -0.7236
A4DAB117_6au5_D_C 6au5 100% -0.6601 6.5 9.0 -0.3185 -0.7007
A4DAB117_5icz_B_A 5icz 100% -0.6782 6.5 9.0 -0.2618 -0.7284
A4DAB117_5ivz_B_A 5ivz 100% -0.6634 6.5 4.0 -0.2878 -0.7075
A4DAB117_5ir1_B_A 5ir1 100% -0.6668 6.5 9.0 -0.2913 -0.7117
A4DAB117_5icx_D_C 5icx 100% -0.651 6.5 9.0 -0.2981 -0.694
A4DAB117_5th2_B_A 5th2 100% -0.6594 6.5 4.0 -0.2861 -0.7047
A4DAB117_6arp_D_C 6arp 98% -0.7346 7.0 4.0 -0.5131 -0.7611
A4DAB117_5icx_B_A 5icx 100% -0.6934 6.5 4.0 -0.3081 -0.7394
A4DAB117_6azl_D_C 6azl 100% -0.6605 6.5 9.0 -0.292 -0.705
A4DAB117_5t1l_B_A 5t1l 100% -0.6613 6.5 4.0 -0.2564 -0.7092
A4DAB117_1yy9_D_C 1yy9 100% -0.6862 6.5 9.0 -0.3108 -0.731
A4DAB117_6axp_B_A 6axp 100% -0.6984 6.5 9.0 -0.3579 -0.739
A4DAB117_5esq_B_A 5esq 100% -0.7025 6.5 4.0 -0.3079 -0.7501
A4DAB117_6ayn_B_A 6ayn 100% -0.6534 6.5 9.0 -0.2645 -0.6999
A4DAB117_6azk_D_C 6azk 100% -0.6388 6.5 4.0 -0.2932 -0.68
A4DAB117_5gz0_B_A 5gz0 98% -0.709 6.5 4.0 -0.3431 -0.7524
A4DAB117_6au5_B_A 6au5 100% -0.6773 6.5 9.0 -0.2764 -0.7251
A4DAB117_5t1k_B_A 5t1k 100% -0.6473 6.5 4.0 -0.2839 -0.6909
A4DAB117_6ayn_D_C 6ayn 100% -0.6517 6.5 9.0 -0.3128 -0.6923
A4DAB117_6arp_B_A 6arp 98% -0.7263 6.5 4.0 -0.5068 -0.7528
A4DAB117_5f88_B_A 5f88 100% -0.6671 6.5 4.0 -0.3081 -0.7103
A4DAB117_5hyq_D_C 5hyq 100% -0.6529 6.5 4.0 -0.3068 -0.6948
A4DAB117_5iop_B_A 5iop 100% -0.7003 6.5 4.0 -0.3463 -0.7429
A4DAB117_1yy8_D_C 1yy8 100% -0.688 6.5 4.0 -0.3512 -0.728
A4DAB117_5ff6_B_A 5ff6 100% -0.6653 6.5 9.0 -0.3027 -0.7085
A4DAB117_5euk_D_C 5euk 100% -0.6737 6.5 4.0 -0.3334 -0.7149
A4DAB117_5id0_D_C 5id0 100% -0.657 6.5 4.0 -0.247 -0.7071
A4DAB117_5ff6_D_C 5ff6 100% -0.6898 6.5 4.0 -0.2901 -0.7385
A4DAB117_5i2i_D_C 5i2i 100% -0.6472 6.5 4.0 -0.278 -0.6916
A4DAB117_4gw1_B_A 4gw1 100% -0.6843 6.5 9.0 -0.3432 -0.7248
A4DAB117_5ir1_D_C 5ir1 100% -0.6855 6.5 9.0 -0.3556 -0.7249