Matuzumab

A4DAB167 | Phase-II
EGFR/ERBB1/HER1
G1 / None
ImClone Systems Merck KGaA Takeda
Phase-II
Whole mAb
EMD 72000 EMD-72000 EMD72000
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IMGT PubChem (135314357) PubChem (160671567) PubChem (347909947) PubChem (348986850) PubChem (387060161) PubChem (468800474) PubChem (472219701) PubChem (472418970) PubChem (481155372) PubChem (486486877) PubChem (488214711) PubChem (505057022) PubChem (505806396) PubChem (519930739) Thera-SAbDab YAbS
Avg A4D Score
-0.7071
Score Range
-0.74 to -0.6
Structures
6
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB167_5vsi_H_L 5vsi 100% -0.7266 6.5 9.0 -0.5606 -0.7469
A4DAB167_3c09_H_L 3c09 99% -0.7353 6.5 9.0 -0.4453 -0.7712
A4DAB167_5vr9_A_B 5vr9 100% -0.7099 6.5 9.0 -0.3358 -0.7545
A4DAB167_5vr9_H_L 5vr9 100% -0.7337 6.5 9.0 -0.5332 -0.758
A4DAB167_3c09_C_B 3c09 99% -0.5982 6.5 9.0 -0.4253 -0.6237
A4DAB167_3c08_H_L 3c08 100% -0.7388 6.5 9.0 N/A N/A