Volagidemab

A4DAB298 | Phase-II
GCCR/NR3C1
G2 / None
Amgen REMD Biotherapeutics
Phase-II
Whole mAb
AMG-477 AMG477 AMB 477 REMD-477 REMD477 REMD 477
—
Avg A4D Score
-0.7118
Score Range
-0.76 to -0.67
Structures
7
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB298_5xez_H_L 5xez 99% -0.7063 6.5 4.0 -0.2622 -0.7689
A4DAB298_4lf3_B_A 4lf3 99% -0.7142 6.5 9.0 -0.3181 -0.77
A4DAB298_5xf1_H_L 5xf1 99% -0.6868 6.5 9.0 -0.2961 -0.7419
A4DAB298_5xf1_C_D 5xf1 99% -0.6734 6.5 9.0 -0.2526 -0.7328
A4DAB298_4lf3_E_D 4lf3 99% -0.7535 6.5 9.0 -0.3789 -0.8063
A4DAB298_5xez_C_D 5xez 99% -0.6864 6.5 4.0 -0.2499 -0.7479
A4DAB298_4ers_H_L 4ers 99% -0.7617 6.5 4.0 -0.3933 -0.8137