MAPIYA contact map server for identification and visualization of molecular interactions in proteins and biological complexes

Nucleic Acids Research, gkac307, 2022

Authors: Aleksandra E Badaczewska-Dawid, Chandran Nithin, Wróblewski Karol, Kurciński Mateusz, Kmiecik Sebastian


Correct identification and effective visualization of interactions in biomolecular structures facilitate understanding of their functions and molecular design. In response to the practical needs of structure-based analysis, we have created a Mapiya web server. The Mapiya integrates four main functionalities: (i) generation of contact maps – intramolecular and intermolecular—for proteins, nucleic acids, and their complexes; (ii) characterization of the interactions physicochemical nature, (iii) interactive visualization of biomolecular conformations with automatic zoom on selected contacts using Molstar and (iv) additional sequence- and structure-based analyses performed with third-party software and in-house algorithms combined into an easy-to-use interface. Thus, Mapiya offers a highly customized analysis of the molecular interactions' in various biological systems. The web server is available at: