Vilastobart

A4DAB294 | Phase-I/II
CTLA4/CD152
G1 / None
Xilio Therapeutics
Phase-I/II
Whole mAb
XTX-101 XTX 101 XTX101
—
Avg A4D Score
-0.7873
Score Range
-0.82 to -0.76
Structures
6
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB294_8g8n_D_E 8g8n 100% -0.7743 6.5 4.0 -0.6921 -0.7835
A4DAB294_8g8n_G_I 8g8n 100% -0.7574 6.5 9.0 -0.5819 -0.7767
A4DAB294_8g8n_H_L 8g8n 100% -0.8108 6.5 9.0 -0.6241 -0.8328
A4DAB294_8g2m_H_L 8g2m 98% -0.8184 6.5 9.0 -0.6201 -0.8406
A4DAB294_8g8n_A_B 8g8n 100% -0.7707 6.5 9.0 -0.6378 -0.7865
A4DAB294_8g8n_K_M 8g8n 100% -0.7924 6.5 4.0 -0.6165 -0.8132